pleconaril

Known as: 3-(3,5-dimethyl-4((3-(3-methyl-5-isoxazolyl)propyl)phenyl)-5-trifluoromethyl)-1,2,4-oxadiazole, 3-[3,5-Dimethyl-4-[3-(3-Methyl-5-Isoxazolyl)Propoxy]Phenyl]-5-(Trifluoromethyl)-1,2,4-Oxadiazole 
A small-molecule inhibitor with activity against viruses in the picornaviridae family, including enterovirus and rhinovirus. Pleconaril binds to a… (More)
National Institutes of Health

Papers overview

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2006
2006
Enteroviral meningitis causes appreciable morbidity in adults, including hospitalization, decreased activity, and headache… (More)
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2005
2005
Pleconaril, a specific inhibitor of human picornaviruses, showed therapeutic efficacy against community-acquired colds caused by… (More)
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Highly Cited
2003
Highly Cited
2003
The novel capsid-binding antiviral pleconaril inhibits in vitro replication of most rhinoviruses and enteroviruses. Oral… (More)
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Review
2003
Review
2003
Despite the availability of therapy for selected symptoms, no specific antiviral agents are available to treat or prevent… (More)
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2003
2003
BACKGROUND Enterovirus (EV) meningitis is common in infants and may have neurologic complications. Treatment of older children… (More)
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Highly Cited
2001
Highly Cited
2001
Enteroviruses usually cause self-limited disease that, although associated with high morbidity, is rarely fatal. In certain… (More)
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2001
2001
Pleconaril (VP-63843) 3-[3,5-dimethyl-4[[3-(3-methyl-5-isoxazolyl)propyl] oly]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole is a… (More)
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2000
2000
BACKGROUND We tested the in vitro activity of pleconaril and AG7088 against five numbered human rhinovirus (HRV) serotypes and 46… (More)
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Highly Cited
1999
Highly Cited
1999
The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most commonly… (More)
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1999
1999
Pleconaril (VP 63843) is a novel orally bioavailable small molecule with broad antipicornavirus (enterovirus and rhinovirus… (More)
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