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pleconaril

Known as: 3-(3,5-dimethyl-4((3-(3-methyl-5-isoxazolyl)propyl)phenyl)-5-trifluoromethyl)-1,2,4-oxadiazole, 3-[3,5-Dimethyl-4-[3-(3-Methyl-5-Isoxazolyl)Propoxy]Phenyl]-5-(Trifluoromethyl)-1,2,4-Oxadiazole 
A small-molecule inhibitor with activity against viruses in the picornaviridae family, including enterovirus and rhinovirus. Pleconaril binds to a… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antiviral AgentsOxadiazoles

Narrower (1)

Picovir

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily attacks motor neurons in the brain… 
Review
2014
Review
2014
The enteroviruses: problems in need of treatments.
Highly Cited
2003
Highly Cited
2003
Efficacy and Safety of Oral Pleconaril for Treatment of Colds Due to Picornaviruses in Adults: Results of 2 Double-Blind, Randomized, Placebo-Controlled Trials
Abstract The novel capsid-binding antiviral pleconaril inhibits in vitro replication of most rhinoviruses and enteroviruses. Oral… 
Highly Cited
2003
Highly Cited
2003
Human rhinovirus capsid dynamics is controlled by canyon flexibility.
Highly Cited
2001
Highly Cited
2001
Treatment of potentially life-threatening enterovirus infections with pleconaril
Enteroviruses usually cause self-limited disease that, although associated with high morbidity, is rarely fatal. In certain… 
Highly Cited
2001
Highly Cited
2001
Pleconaril: a novel antipicornaviral drug
Pleconaril (VP-63843) 3-[3,5-dimethyl-4[[3-(3-methyl-5-isoxazolyl)propyl] oly]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole is a… 
Highly Cited
2000
Highly Cited
2000
Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection.
A randomized, double-blind study assessed the efficacy and safety of pleconaril, a novel antiviral drug with broad-spectrum… 
2000
2000
Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network.
BACKGROUND Pleconaril is an orally active, broad spectrum antipicornaviral agent with activity against nonpolio enteroviruses… 
Highly Cited
1999
Highly Cited
1999
Activity of Pleconaril against Enteroviruses
ABSTRACT The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most… 
Highly Cited
1999
Highly Cited
1999
Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants.
Pleconaril (VP 63843) is a novel orally bioavailable small molecule with broad antipicornavirus (enterovirus and rhinovirus… 
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