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pleconaril

Known as: 3-(3,5-dimethyl-4((3-(3-methyl-5-isoxazolyl)propyl)phenyl)-5-trifluoromethyl)-1,2,4-oxadiazole, 3-[3,5-Dimethyl-4-[3-(3-Methyl-5-Isoxazolyl)Propoxy]Phenyl]-5-(Trifluoromethyl)-1,2,4-Oxadiazole 
A small-molecule inhibitor with activity against viruses in the picornaviridae family, including enterovirus and rhinovirus. Pleconaril binds to a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Enterovirus 71(EV71) causes recurring outbreaks of hand, foot and mouth disease and encephalitis leading to complications or… Expand
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Review
2010
Review
2010
Hand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT Enteroviral meningitis causes appreciable morbidity in adults, including hospitalization, decreased activity, and… Expand
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Highly Cited
2003
Highly Cited
2003
Abstract The novel capsid-binding antiviral pleconaril inhibits in vitro replication of most rhinoviruses and enteroviruses. Oral… Expand
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Highly Cited
2001
Highly Cited
2001
Enteroviruses usually cause self-limited disease that, although associated with high morbidity, is rarely fatal. In certain… Expand
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Highly Cited
2001
Highly Cited
2001
  • J. Romero
  • Expert opinion on investigational drugs
  • 2001
  • Corpus ID: 25282867
Pleconaril (VP-63843) 3-[3,5-dimethyl-4[[3-(3-methyl-5-isoxazolyl)propyl] oly]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole is a… Expand
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Highly Cited
2000
Highly Cited
2000
A randomized, double-blind study assessed the efficacy and safety of pleconaril, a novel antiviral drug with broad-spectrum… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND We tested the in vitro activity of pleconaril and AG7088 against five numbered human rhinovirus (HRV) serotypes and 46… Expand
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2000
2000
Background. Pleconaril is an orally active, broad spectrum antipicornaviral agent with activity against nonpolio enteroviruses… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most… Expand
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