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pleconaril

Known as: 3-(3,5-dimethyl-4((3-(3-methyl-5-isoxazolyl)propyl)phenyl)-5-trifluoromethyl)-1,2,4-oxadiazole, 3-[3,5-Dimethyl-4-[3-(3-Methyl-5-Isoxazolyl)Propoxy]Phenyl]-5-(Trifluoromethyl)-1,2,4-Oxadiazole 
A small-molecule inhibitor with activity against viruses in the picornaviridae family, including enterovirus and rhinovirus. Pleconaril binds to a… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antiviral AgentsOxadiazoles

Narrower (1)

Picovir

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Current status of anti-picornavirus therapies.
Picornaviruses are important human pathogens causing severe morbidity and some mortality with the potential to cause worldwide… 
2006
2006
The Effect of Oral Pleconaril on Hepatic Cytochrome P450 3A Activity in Healthy Adults Using Intravenous Midazolam as a Probe
Pleconaril is a viral capsid inhibitor under evaluation for treatment of infections caused by rhinoviruses and enteroviruses… 
Highly Cited
2005
Highly Cited
2005
2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder.
2005
2005
Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication.
OBJECTIVES During this study, novel biphenyl derivatives were synthesized and tested for antiviral activity. METHODS A new… 
2003
2003
Safety and efficacy evaluation of pleconaril for treatment of the common cold.
losis under routine conditions with additional information on side effects and contact tracing. Tuber Lung Dis 1996; 77:425–8. 7… 
2003
2003
SPECT scans for monitoring response to pleconaril therapy in chronic enteroviral meningoencephalitis.
Chronic enteroviral meningoencephalitis (CEMA) is a rare complication of immunodeficient individuals and may present as insidious… 
Highly Cited
2003
Highly Cited
2003
A fatal case of coxsackievirus B4 meningoencephalitis.
BACKGROUND Coxsackieviruses and echoviruses are common causes of aseptic meningitis, but they rarely cause life-threatening… 
Review
2001
Review
2001
Recent advances in the treatment of rhinovirus infections.
  • M. Mckinlay
  • Current opinion in pharmacology (Print)
  • 2001
  • Corpus ID: 1366433
2000
2000
Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network.
BACKGROUND Pleconaril is an orally active, broad spectrum antipicornaviral agent with activity against nonpolio enteroviruses… 
Review
2000
Review
2000
Influenza virus and rhinovirus-related otitis media: potential for antiviral intervention
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