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platelet protein P47
Known as:
47KDa platelet protein
, platelet 47k protein
, pleckstrin
National Institutes of Health
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Related topics
Related topics
5 relations
Broader (2)
Blood Proteins
Phosphoproteins
PLEK gene
Narrower (2)
PLEK protein, human
Plek protein, mouse
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Proteasome subunit Rpn13 is a novel ubiquitin receptor
K. Husnjak
,
S. Elsasser
,
+7 authors
I. Dikic
Nature
2008
Corpus ID: 4406904
Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation…
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Highly Cited
2008
Highly Cited
2008
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
P. Schreiner
,
Xiang Chen
,
+7 authors
M. Groll
Nature
2008
Corpus ID: 4309828
Targeted protein degradation is largely performed by the ubiquitin–proteasome pathway, in which substrate proteins are marked by…
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Highly Cited
2004
Highly Cited
2004
Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in…
Liansheng Sun
,
G. Mao
,
A. Rao
Blood
2004
Corpus ID: 25209016
The mechanisms by which agonists activate glycoprotein (GP) IIb-IIIa function remain unclear. We have reported data on a patient…
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Highly Cited
2004
Highly Cited
2004
Genetically encoded FRET probe for PKC activity based on pleckstrin.
A. Schleifenbaum
,
G. Stier
,
A. Gasch
,
M. Sattler
,
C. Schultz
Journal of the American Chemical Society
2004
Corpus ID: 10184657
We developed a probe for investigating protein kinase C (PKC) activity in living cells. The probe is based on a fragment of…
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Highly Cited
1997
Highly Cited
1997
Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain
A. D. Ma
,
L. Brass
,
C. Abrams
Journal of Cell Biology
1997
Corpus ID: 693185
Pleckstrin homology (PH) domains are sequences of ∼100 amino acids that form “modules” that have been proposed to facilitate…
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Highly Cited
1995
Highly Cited
1995
Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain (*)
C. Abrams
,
Wei Zhao
,
E. Belmonte
,
L. Brass
Journal of Biological Chemistry
1995
Corpus ID: 38824485
Pleckstrin is a substrate for protein kinase C in activated platelets that contains at its N and C termini two of the pleckstrin…
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Highly Cited
1995
Highly Cited
1995
Phosphatidylinositol(3, 4, 5) -Trisphosphate Stimulates Phosphorylation of Pleckstrin in Human Platelets (*)
Jun Zhang
,
J. Falck
,
K. K. Reddy
,
C. Abrams
,
Wei Zhao
,
S. Rittenhouse
Journal of Biological Chemistry
1995
Corpus ID: 39198060
We have reported that platelets exposed to thrombin or thrombin receptor-directed ligand activate phospholipase C and rapidly…
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Review
1994
Review
1994
Pleckstrin homology (PH) domains in signal transducton
E. Ingley
,
B. Hemmings
Journal of Cellular Biochemistry
1994
Corpus ID: 23154429
A diverse array of molecules involved in signal transduction have recently been recognised as containing a new homology domain…
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1992
1992
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
Y. Yatomi
,
O. Hazeki
,
S. Kume
,
M. Ui
Biochemical Journal
1992
Corpus ID: 45129025
Studies were made of inhibition by wortmannin, a fungal metabolite, of human platelet responses to various stimuli. Wortmannin at…
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Highly Cited
1989
Highly Cited
1989
Molecular analysis of pleckstrin: The major protein kinase c substrate of platelets
M. Tyers
,
R. Haslam
,
R. Rachubinski
,
C. Harley
Journal of Cellular Biochemistry
1989
Corpus ID: 23979756
Activation of protein kinase C (PKC) in platelets causes the immediate phosphorylation of pleckstrin, an apparent Mr 40–47,000…
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