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Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation… Expand Targeted protein degradation is largely performed by the ubiquitin–proteasome pathway, in which substrate proteins are marked by… Expand The mechanisms by which agonists activate glycoprotein (GP) IIb-IIIa function remain unclear. We have reported data on a patient… Expand We developed a probe for investigating protein kinase C (PKC) activity in living cells. The probe is based on a fragment of… Expand Pleckstrin homology (PH) domains are sequences of ∼100 amino acids that form “modules” that have been proposed to facilitate… Expand Pleckstrin is a substrate for protein kinase C in activated platelets that contains at its N and C termini two of the pleckstrin… Expand We have reported that platelets exposed to thrombin or thrombin receptor-directed ligand activate phospholipase C and rapidly… Expand A diverse array of molecules involved in signal transduction have recently been recognised as containing a new homology domain… Expand Studies were made of inhibition by wortmannin, a fungal metabolite, of human platelet responses to various stimuli. Wortmannin at… Expand Activation of protein kinase C (PKC) in platelets causes the immediate phosphorylation of pleckstrin, an apparent Mr 40–47,000… Expand