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platelet protein P47

Known as: 47KDa platelet protein, platelet 47k protein, pleckstrin 
 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Blood ProteinsPhosphoproteins
PLEK gene

Narrower (2)

PLEK protein, humanPlek protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis.
Pleckstrin, the platelet and leukocyte C kinase substrate, is a prominent substrate of PKC in platelets, monocytes, macrophages… Expand
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Highly Cited
2008
Highly Cited
2008
Proteasome subunit Rpn13 is a novel ubiquitin receptor
Proteasomal receptors that recognize ubiquitin chains attached to substrates are key mediators of selective protein degradation… Expand
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Highly Cited
2008
Highly Cited
2008
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
Targeted protein degradation is largely performed by the ubiquitin–proteasome pathway, in which substrate proteins are marked by… Expand
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2007
2007
Phosphorylation of Pleckstrin Increases Proinflammatory Cytokine Secretion by Mononuclear Phagocytes in Diabetes Mellitus1
The protein kinase C (PKC) family of intracellular enzymes plays a crucial role in signal transduction for a variety of cellular… Expand
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Highly Cited
2004
Highly Cited
2004
Genetically encoded FRET probe for PKC activity based on pleckstrin.
We developed a probe for investigating protein kinase C (PKC) activity in living cells. The probe is based on a fragment of… Expand
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Highly Cited
2004
Highly Cited
2004
Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in…
The mechanisms by which agonists activate glycoprotein (GP) IIb-IIIa function remain unclear. We have reported data on a patient… Expand
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2000
2000
Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting…
Previous experiments suggest that actin disassembly, perhaps at a specific site, is required for platelet secretion. Platelet… Expand
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Highly Cited
1999
Highly Cited
1999
LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI
ABSTRACT In the present study, we have addressed the role of the linker for activation of T cells (LAT) in the regulation of… Expand
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1997
1997
Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain
Pleckstrin homology (PH) domains are sequences of ∼100 amino acids that form “modules” that have been proposed to facilitate… Expand
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1995
1995
Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain (*)
Pleckstrin is a substrate for protein kinase C in activated platelets that contains at its N and C termini two of the pleckstrin… Expand
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