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platelet protein P47
Known as:
47KDa platelet protein
, platelet 47k protein
, pleckstrin
National Institutes of Health
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Related topics
Related topics
5 relations
Broader (2)
Blood Proteins
Phosphoproteins
PLEK gene
Narrower (2)
PLEK protein, human
Plek protein, mouse
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Proteomic identification of pleckstrin‐associated proteins in platelets: Possible interactions with actin
A. Baig
,
X. Bao
,
R. Haslam
Proteomics
2009
Corpus ID: 43389306
Pleckstrin (plek)‐null platelets from a knockout mouse have been shown to be defective in granule secretion, aggregation and…
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2004
2004
Structure and dynamics of the human pleckstrin DEP domain: Distinct molecular features of a novel DEP domain subfamily
C. Civera
,
B. Simon
,
G. Stier
,
M. Sattler
,
M. Macias
Proteins: Structure, Function, and Bioinformatics
2004
Corpus ID: 45722575
Pleckstrin1 is a major substrate for protein kinase C in platelets and leukocytes, and comprises a central DEP (disheveled, Egl…
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Highly Cited
1999
Highly Cited
1999
Recruitment of Pleckstrin and Phosphoinositide 3-Kinase γ into the Cell Membranes, and Their Association with Gβγ After Activation of NK Cells with Chemokines
A. Al‐Aoukaty
,
B. Rolstad
,
A. Maghazachi
Journal of Immunology
1999
Corpus ID: 83536142
The role of phosphoinositide 3 kinases (PI 3-K) in chemokine-induced NK cell chemotaxis was investigated. Pretreatment of NK…
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Review
1999
Review
1999
Pleckstrin Homology Domains and Phospholipid-Induced Cytoskeletal Reorganization
A. Ma
,
C. Abrams
Thrombosis and Haemostasis
1999
Corpus ID: 43835124
Introduction A remarkable event that takes place during platelet activation is the reorganization that occurs when platelets…
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Highly Cited
1997
Highly Cited
1997
Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain
A. Ma
,
L. Brass
,
C. Abrams
Journal of Cell Biology
1997
Corpus ID: 693185
Pleckstrin homology (PH) domains are sequences of ∼100 amino acids that form “modules” that have been proposed to facilitate…
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Highly Cited
1996
Highly Cited
1996
Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective…
X. Yang
,
L. Sun
,
S. Ghosh
,
A. Rao
Blood
1996
Corpus ID: 1529223
Signal transduction on platelet activation involves phosphoinositide-specific phospholipase C (PLC)-mediated hydrolysis of…
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1996
1996
Phosphopleckstrin Inhibits Gβγ-activable Platelet Phosphatidylinositol-4,5-bisphosphate 3-Kinase*
Charles S. Abrams
,
Jin Zhang
,
C. Downes
,
Xiu-wen Tang
,
Wei Zhao
,
S. Rittenhouse
Journal of Biological Chemistry
1996
Corpus ID: 2117337
Pleckstrin, the prototypic protein containing two copies of the pleckstrin homology domain, is a prominent substrate of protein…
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Highly Cited
1995
Highly Cited
1995
Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain (*)
C. Abrams
,
Wei Zhao
,
E. Belmonte
,
L. Brass
Journal of Biological Chemistry
1995
Corpus ID: 38824485
Pleckstrin is a substrate for protein kinase C in activated platelets that contains at its N and C termini two of the pleckstrin…
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1995
1995
Diacylglycerol elevations in control platelets are unaccompanied by pleckstrin phosphorylation. Implications for the role of diacylglycerol in platelet activation.
Miriam H. Fukami
,
Holm Holmsen
European Journal of Biochemistry
1995
Corpus ID: 23371388
Several laboratories have reported that diacylglycerol levels in human platelets (approximately 100 pmol/10(9) platelets…
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1992
1992
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
Y. Yatomi
,
O. Hazeki
,
S. Kume
,
M. Ui
Biochemical Journal
1992
Corpus ID: 45129025
Studies were made of inhibition by wortmannin, a fungal metabolite, of human platelet responses to various stimuli. Wortmannin at…
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