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PLEK gene

Known as: PLATELET AND LEUKOCYTE C KINASE SUBSTRATE, PLEK, PLATELET P47 
National Institutes of Health

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2 relations
PLEK protein, humanplatelet protein P47

Papers overview

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2006
2006
A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation.
The low affinity receptor for immunoglobulin G, FcgammaRIIA, is expressed in human platelets, mediates heparin-induced… 
1998
1998
Conformational stability studies of the pleckstrin DEP domain: definition of the domain boundaries.
Highly Cited
1997
Highly Cited
1997
Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain
Pleckstrin homology (PH) domains are sequences of ∼100 amino acids that form “modules” that have been proposed to facilitate… 
Highly Cited
1997
Highly Cited
1997
The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1).
The solution structure of the pleckstrin homology (PH) domain of mouse Son-of-sevenless 1 (mSos1), a guanine nucleotide exchange… 
Highly Cited
1996
Highly Cited
1996
Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective…
Signal transduction on platelet activation involves phosphoinositide-specific phospholipase C (PLC)-mediated hydrolysis of… 
Highly Cited
1995
Highly Cited
1995
Identification of Rlk, a Novel Protein Tyrosine Kinase with Predominant Expression in the T Cell Lineage (*)
The control of phosphorylation by protein tyrosine kinases represents an important regulatory mechanism in T cell growth… 
Highly Cited
1995
Highly Cited
1995
Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain (*)
Pleckstrin is a substrate for protein kinase C in activated platelets that contains at its N and C termini two of the pleckstrin… 
Highly Cited
1993
Highly Cited
1993
A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets.
The peptide YFLLRNP antagonizes the aggregation of human platelets when induced by low concentrations of alpha-thrombin or the… 
Highly Cited
1992
Highly Cited
1992
Cytosolic calcium as a second messenger for collagen-induced platelet responses.
We showed previously that direct platelet activation by collagen involves an increase in the platelet cytosolic free Ca2… 
1992
1992
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
Studies were made of inhibition by wortmannin, a fungal metabolite, of human platelet responses to various stimuli. Wortmannin at… 
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