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PLEK gene

Known as: PLATELET AND LEUKOCYTE C KINASE SUBSTRATE, PLEK, PLATELET P47 
National Institutes of Health

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Related topics

2 relations
PLEK protein, humanplatelet protein P47

Papers overview

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2004
2004
Structure and dynamics of the human pleckstrin DEP domain: Distinct molecular features of a novel DEP domain subfamily
Pleckstrin1 is a major substrate for protein kinase C in platelets and leukocytes, and comprises a central DEP (disheveled, Egl… 
1998
1998
Platelets from eclampsia patients have reduced membrane microviscosity and lower activities of the signalling enzymes.
Highly Cited
1997
Highly Cited
1997
Pleckstrin Associates with Plasma Membranes and Induces the Formation of Membrane Projections: Requirements for Phosphorylation and the NH2-terminal PH Domain
Pleckstrin homology (PH) domains are sequences of ∼100 amino acids that form “modules” that have been proposed to facilitate… 
Highly Cited
1997
Highly Cited
1997
The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1).
The solution structure of the pleckstrin homology (PH) domain of mouse Son-of-sevenless 1 (mSos1), a guanine nucleotide exchange… 
Highly Cited
1996
Highly Cited
1996
Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective…
Signal transduction on platelet activation involves phosphoinositide-specific phospholipase C (PLC)-mediated hydrolysis of… 
1996
1996
A site of interaction between pleckstrin's PH domains and Gβγ
Highly Cited
1995
Highly Cited
1995
Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain (*)
Pleckstrin is a substrate for protein kinase C in activated platelets that contains at its N and C termini two of the pleckstrin… 
Highly Cited
1993
Highly Cited
1993
A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets.
The peptide YFLLRNP antagonizes the aggregation of human platelets when induced by low concentrations of alpha-thrombin or the… 
1993
1993
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol…
The primary phase of ADP-induced aggregation of human platelets does not involve appreciable formation of thromboxane A2 or… 
1992
1992
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
Studies were made of inhibition by wortmannin, a fungal metabolite, of human platelet responses to various stimuli. Wortmannin at… 
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