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Cyclic nucleotides and phosphodiesterases in platelets.
This chapter describes platelet PDEs and indicates that cross-talk between the cAMP and cGMP systems may occur on at least two levels, affecting both cyclic nucleotide phosphodiesterase (PDE) and protein kinase activities. Expand
Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle.
- D. Maurice, D. Crankshaw, R. Haslam
- Chemistry, Medicine
- European journal of pharmacology
- 10 January 1991
Synergism between nitrovasodilators and isoprenaline, an activator of adenylyl cyclase, could be detected in vascular smooth muscle and was particularly marked when inhibition of contraction was studied. Expand
Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP.
The results show that cyclic AMP plays no significant role in the responses of platelets to aggregating agents in the absence of compounds that increase the platelet cyclicAMP concentration above the resting value. Expand
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.
Although cyclic GMP may mediate the inhibition of rabbit platelet function by high concentrations of nitrovasodilators added alone, the synergistic interaction of lower concentrations with PGE1 depends on an enhanced accumulation of cyclic AMP. Expand
Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation.
Much of the effect of NP with EHNA is mediated by cAMP, and PDE2 plays a major role in the hydrolysis of low cAMP concentrations and restricts any increases in cAMP concentration and decreases in platelet aggregation caused by the inhibition of PDE3. Expand
Nitroprusside enhances isoprenaline-induced increases in cAMP in rat aortic smooth muscle.
It is concluded that cAMP is likely to mediate the synergistic inhibition of the contraction of rat aortic smooth muscle by these compounds. Expand
THE METABOLISM OF GLUTAMATE IN HOMOGENATES AND SLICES OF BRAIN CORTEX.
A review of the literature on biophy8 and its applications in medicine and science over the past 60 years, as well as some of the contributions of recent authors, finds that the field has come a long way in a short period of time. Expand
Effects of adenosine on levels of adenosine cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation.
The results show that platelets possess a specific extracellular membrane receptor for adenosine, which is distinct from that for ADP and which mediates the inhibition of platelet function byadenosine by activating platelet adenylate cyclase. Expand
Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine.
- R. Haslam, J. Lynham
- Chemistry, Medicine
- Life sciences. Pt. 2: Biochemistry, general and…
- 8 December 1972
The results suggest that the activation and inhibition of platelet adenylatecyclase by adenosine or 2-chloroadenosine are independent processes mediated by different components of a receptor-adenylate cyclase complex. Expand