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pironetin

Known as: 5-ethyl-5,6-dihydro-6-(2-hydroxy-4-methoxy-3,5-dimethyl-7-nonenyl)-2H-pyran-2-one 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

PA 48153C

Broader (1)

Pyrones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (-)-Pironetin.
Pironetin, the only crystallographically confirmed natural product to target α-tubulin, displays potent cytotoxic activity… 
2015
2015
The Mechanism of the Interactions of Pironetin Analog/Combretastatin A‐4 Hybrids with Tubulin
We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting… 
2011
2011
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules.
2009
2009
Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis
Bcl-xL, an anti-apoptotic Bcl-2 family member protein, contributes to the resistance against chemotherapies such as tubulin… 
2007
2007
Asymmetric total synthesis of (-)-pironetin employing the SAMP/RAMP hydrazone methodology.
A convergent asymmetric total synthesis of pironetin (1), a polyketide with immunosuppressive, antitumor, and plant-growth… 
2003
2003
Total synthesis of (-)-pironetin.
[structure: see text] The asymmetric total synthesis of pironetin, a compound that shows plant growth regulatory activity… 
2001
2001
Total synthesis of the immunosupressant (-)-pironetin (PA48153C).
[reaction: see text]. Total synthesis of the immunosuppresant pironetin has been achieved by a synthetic route in which the… 
Highly Cited
1999
Highly Cited
1999
Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin.
We reported previously that pironetin and its derivatives were potent inhibitors of cell cycle progression at the M-phase and… 
Highly Cited
1998
Highly Cited
1998
Cell cycle arrest and antitumor activity of pironetin and its derivatives.
1995
1995
Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK10958. III. Biosynthesis.
A novel plant growth regulator, pironetin was isolated from the culture broth of Streptomyces sp. NK10958. The structure of… 
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