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The purpose of this study was to evaluate factors for improving the in vitro buoyancy and the drug release characteristics of… Expand Sometimes novel treatments arise from chance observations made with existing drugs. The beneficial effects of an inhaled diuretic… Expand Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote… Expand To modify the release rate of piretanide, a potent loop diuretic, a double-layer tablet was designed, and in vitro release was… Expand 1. Neuropeptide Y (NPY), peptide YY (PYY) and, to a lesser extent, human pancreatic polypeptide (HPP) reduced short‐circuit… Expand Piretanide is a new loop diuretic similar to furosemide in pharmacologic properties and approximately six times as potent. We… Expand The actions of gamma-aminobutyric acid (GABA) and its analogues, 3-amino-1-propanesulphonic acid (3APS) and baclofen, have been… Expand THE mechanism of chloride transport in epithelia is still obscure, although it is the dominant process in many tissues, including… Expand In a comparative study with the use of a randomized crossover design, piretanide, a new “loop” diuretic, was given intravenously… Expand 1. The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared… Expand