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Mechanisms of cisplatin-induced ototoxicity and prevention
This review summarizes recent data that shed new light on the mechanisms of cisplatin ototoxicity and its prevention and recommends the application of agents that act further downstream in the cell death cascade to prevent apoptosis and hearing loss. Expand
Mechanisms of cisplatin ototoxicity and progress in otoprotection
  • L. Rybak
  • Medicine
  • Current opinion in otolaryngology & head and neck…
  • 1 October 2007
This review presents exciting new data published in the past year that help to elucidate the mechanisms of cisplatin ototoxicity and could lead to important clinical trials to determine whether the findings in experimental animals can translate into effective treatments to prevent cisPlatin ottoxicity. Expand
Ototoxicity: therapeutic opportunities.
Challenges and opportunities exist for appropriate drug delivery to the inner ear and for avoiding interference with the therapeutic efficacy of both categories of ototoxic drugs. Expand
Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention
This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy classes of drugs, discusses oxidative stress in the inner ear as a primary trigger for cell damage,Expand
Cisplatin ototoxicity and protection: clinical and experimental studies.
Recent important clinical and experimental investigations of cisplatin ototoxicity are summarized and the utility of protective agents employed in patients and in experimental animals is discussed. Expand
Mechanism of cisplatin ototoxicity: antioxidant system.
Cisplatin ototoxicity was evidenced as elevated hearing thresholds and prolonged wave I latencies in response to various stimuli on ABRs, and superoxide dismutase, catalase activities and malondialdehyde levels were significantly increased in the cochleae of cisplatin injected rats. Expand
Application of Antioxidants and Other Agents to Prevent Cisplatin Ototoxicity
The hypothesis that cisplatin ototoxicity is related to depletion of glutathione and antioxidant enzymes in the cochlea and that the use of antioxidants or protective agents would protect the coChlea against cisPlatin damage and prevent hearing loss is tested. Expand
Adenosine Receptors: Expression, Function and Regulation
The biochemical characteristics and signaling cascade associated with each receptor are described and insight is provided into how these receptors are regulated in response to agonists are provided. Expand
Effect of exercise training on antioxidant system in brain regions of rat
Different brain regions contained different activities of antioxidant enzymes, as well as GSH and GSSG levels, which were preferentially altered as a result of exercise training to cope with oxidative stress, and different brain regions showed GSH-Px activity in decreasing order. Expand
d-Methionine provides excellent protection from cisplatin ototoxicity in the rat
D-methionine (D-Met), a sulfur containing compound, was tested as an otoprotectant in male Wistar rats and provided excellent o toprotection even at the lowest level with complete o Toprotection obtained for the 300 mg/kg dosing as measured by both ABR and SEM. Expand