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piquindone

Known as: 2,6-dimethyl-3-ethyl-4,4a,5,6,7,8,8a,9-octahydro-4a,8a-1H-pyrrolo(2,3g)isoquinolin-4-one, 3-ethyl-2,6-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-4a,8a-1H-pyrrolo(2,3g)isoquinolin-4-one 
National Institutes of Health

Papers overview

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1997
1997
The incorporation of butyrophenones and related compounds into a pharmacophore for dopamine D2 antagonists.
This study is an attempt to incorporate the butyrophenones, an important class of nontricyclic antipsychotic drugs, into a… 
1996
1996
Dopamine D2 receptor model explains binding affinity of neuroleptics: piquindone and its structure activity relationships.
Highly Cited
1989
Highly Cited
1989
The induction of grooming and vacuous chewing by a series of selective D-1 dopamine receptor agonists: two directions of D-1:D-2 interaction.
1989
1989
Structural requirements of Na+-dependent antidopaminergic agents: Tropapride, Piquindone, Zetidoline, and Metoclopramide Comparison with Na+-independent ligands
SummaryMolecular graphic design coupled with PCILO and crystallographic results have been used to investigate the three… 
1989
1989
Stereoelectronic study of zetidoline, a dopamine D2 receptor antagonist.
A combination of experimental and theoretical methods were used to investigate the stereoelectronic structure of zetidoline, a… 
1987
1987
The efficacy of piquindone, a new atypical neuroleptic, in the treatment of the positive and negative symptoms of schizophrenia.
Piquindone (RO22-1319), a new "atypical" neuroleptic, was administered for 2 weeks to 37 schizophrenic patients, and the effects… 
1987
1987
Crystallographic, theoretical and molecular modelling studies on the conformations of the salicylamide, raclopride, a selective dopamine‐D2 antagonist *
The structure of the potent dopamine‐D2 antagonist, raclopride, (S)‐3,5‐dichloro‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐6… 
1986
1986
Improvement of symptoms in Tourette syndrome by piquindone, a novel dopamine-2 receptor antagonist.
We have hypothesized that symptoms of Tourette Syndrome (TS) may represent D2 (dopamine-2) receptor hyperactivity. We treated 4… 
1986
1986
Case report of four patients with Tourette syndrome treated with piquindone, a D2 receptor antagonist.
1984
1984
[3H]Ro 22-1319 (piquindone) binds to the D2 dopaminergic receptor subtype in a sodium-dependent manner.
Ro 22-1319, a novel pyrroloisoquinoline compound, is a potent antipsychotic agent with low potential for extrapyramidal effects… 
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