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piquindone

Known as: 2,6-dimethyl-3-ethyl-4,4a,5,6,7,8,8a,9-octahydro-4a,8a-1H-pyrrolo(2,3g)isoquinolin-4-one, 3-ethyl-2,6-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-4a,8a-1H-pyrrolo(2,3g)isoquinolin-4-one 
 
National Institutes of Health

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Highly Cited
1989
Highly Cited
1989
A range of 3- and 6-substituted 1-phenyl-1H-3-benzazepine analogues of SK&F 38393 with D-1 agonist activity were compared for… Expand
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1989
1989
SummaryMolecular graphic design coupled with PCILO and crystallographic results have been used to investigate the three… Expand
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1987
1987
Piquindone (RO22-1319), a new "atypical" neuroleptic, was administered for 2 weeks to 37 schizophrenic patients, and the effects… Expand
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1987
1987
The structure of the potent dopamine-D2 antagonist, raclopride, (S)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6… Expand
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1986
1986
The ability of dopamine agonists and antagonists to compete with [3H]spiperone binding to rat striatal membrane preparations at 4… Expand
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1986
1986
We have hypothesized that symptoms of Tourette Syndrome (TS) may represent D2 (dopamine-2) receptor hyperactivity. We treated 4… Expand
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1986
1986
This report describes a rapid, sensitive and selective method for the determination of piquindone in canine plasma and piquindone… Expand
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1985
1985
It is now 30 years since the introduction of neuroleptics into clinical practice, and we are still learning more about the… Expand
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1984
1984
Ro 22-1319, a novel pyrroloisoquinoline compound, is a potent antipsychotic agent with low potential for extrapyramidal effects… Expand
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