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Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrain.
We characterized the binding of [125I]epidepride to dopamine D2-like and D3-like receptors in tissue sections of human striatum. The competition for binding of [125I]epidepride by domperidone,Expand
The induction of grooming and vacuous chewing by a series of selective D-1 dopamine receptor agonists: two directions of D-1:D-2 interaction.
A range of 3- and 6-substituted 1-phenyl-1H-3-benzazepine analogues of SK&F 38393 with D-1 agonist activity were compared for their behavioural effects in the intact adult rat and for their relativeExpand
Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia
The identification of five dopamine receptor subtypes has given the dopamine hypothesis of schizophrenia new life. The D4 receptor is particularly intriguing because it binds clozapine with highExpand
Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats
Despite multiple lines of investigation the effect of neuroleptics on glutamate‐mediated neurotransmission remains controversial. To study the effects of typical and atypical neuroleptics on selectedExpand
A postmortem study of frontal cortical dopamine D1 receptors in schizophrenics, psychiatric controls, and normal controls
We tested the hypothesis that aberrant dopaminergic innervation in frontal and cingulate cortices of schizophrenic patients might be revealed by examining dopamine D1 receptor density in these brainExpand
The interaction of clozapine with dopamine D1 versus dopamine D2 receptor-mediated function: behavioural indices.
Studies were undertaken to clarify further the mechanism(s) of action of the atypical neuroleptic clozapine, using a behavioural model with the ability to distinguish between relative antagonism ofExpand
Distribution of dopamine D1‐D4 receptor subtypes in human dorsal vagal complex
The distribution of D1/D5, D2/D3, D2/D3/D4, and individually, putative D2‐D4 receptors across the dorsal vagal complex of the human medulla was assessed with quantitative receptor autoradiography.Expand
New putative selective agonists at the D-1 dopamine receptor: Behavioural and neurochemical comparison of CY 208-243 with SK&F 101384 and SK&F 103243
Three putative D-1 agonists with nonbenzazepine structures were compared with the prototype benzazepine D-1 partial agonist SK&F 38393 for their behavioural effects in the intact adult rat, and forExpand
Visualization of dopamine D3-like receptors in human brain with [125I]epidepride.
In sections of human brain containing the striatum (caudate, nucleus, putamen, nucleus accumbens) the competition for binding of [125I]epidepride by compounds with differing selectivity for dopamineExpand
Age-related changes in the regulation of behavior by D-1:D-2 dopamine receptor interactions
Functional interactions between D-1 and D-2 dopamine receptor systems appear important in the regulation of psychomotor behavior, and may alter with aging. Male Sprague-Dawley rats of 5 and 20-24Expand