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phthalazine

National Institutes of Health

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Phthalazines

Papers overview

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Highly Cited
2016
Highly Cited
2016
1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation.
Review
2012
Review
2012
Some recent approaches of biologically active substituted pyridazine and phthalazine drugs.
  • M. Asif
  • Current medicinal chemistry
  • 2012
  • Corpus ID: 35099203
Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and phthalazines are important structural feature of… 
Highly Cited
2006
Highly Cited
2006
Aqueous N-heterocyclization of primary amines and hydrazines with dihalides: microwave-assisted syntheses of N-azacycloalkanes, isoindole, pyrazole, pyrazolidine, and phthalazine derivatives.
  • Y. Ju, R. Varma
  • The Journal of organic chemistry
  • 2006
  • Corpus ID: 12359005
[reactions: see text] The synthesis of nitrogen-containing heterocycles from alkyl dihalides (ditosylates) and primary amines and… 
Highly Cited
2005
Highly Cited
2005
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine…
Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores… 
Review
2002
Review
2002
Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.
Highly Cited
2000
Highly Cited
2000
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after…
PTK787/ZK 222584 (1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate) is a potent inhibitor of vascular endothelial… 
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Highly Cited
2000
Highly Cited
2000
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.
Malignant pleural effusion (PE) is associated with advanced human lung cancer. We found recently, using a nude mouse model, that… 
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Highly Cited
1998
Highly Cited
1998
4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted… 
Highly Cited
1990
Highly Cited
1990
Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.
A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested… 
Highly Cited
1950
Highly Cited
1950
Renal Hyperemia Induced in Man by a New Phthalazine Derivative
  • F. Reubi
  • Proceedings of the Society for Experimental…
  • 1950
  • Corpus ID: 32603042
Pyrogen is the only substance which has been reported to increase significantly the renal blood flow in man. However, according… 
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