phthalazine

 
National Institutes of Health

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Phthalazines

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Review
2012
Review
2012
Some recent approaches of biologically active substituted pyridazine and phthalazine drugs.
Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and phthalazines are important structural feature of… (More)
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Highly Cited
2011
Highly Cited
2011
A catalytically silent FAAH-1 variant drives anandamide transport in neurons
The endocannabinoid anandamide is removed from the synaptic space by a selective transport system, expressed in neurons and… (More)
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2010
2010
Synthesis and antitumor activities of novel 1,4-disubstituted phthalazine derivatives.
In an attempt to develop potent and selective antitumor agents, a series of novel 1,4-disubstituted phthalazine derivatives was… (More)
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2005
2005
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine…
Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores… (More)
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Review
2004
Review
2004
Human liver aldehyde oxidase: inhibition by 239 drugs.
The authors tested 239 frequently used drugs and other compounds for their potential to inhibit the drug-metabolizing enzyme… (More)
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Highly Cited
2000
Highly Cited
2000
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after…
PTK787/ZK 222584 (1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate) is a potent inhibitor of vascular endothelial… (More)
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Highly Cited
2000
Highly Cited
2000
PTK 787 / ZK 222584 , a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases , Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth…
PTK787/ZK 222584 (1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate) is a potent inhibitor of vascular endothelial… (More)
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1995
1995
Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon.
Partially purified aldehyde oxidase (EC 1.2.3.1) has been prepared from human, rabbit, guinea pig, and baboon liver by heat… (More)
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1990
1990
1-substituted phthalazines as probes of the substrate-binding site of mammalian molybdenum hydroxylases.
The interaction of a series of 1-substituted phthalazine derivatives with partially purified aldehyde oxidase from rabbit, guinea… (More)
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1984
1984
Elevation of molybdenum hydroxylase levels in rabbit liver after ingestion of phthalazine or its hydroxylated metabolite.
Oral administration of phthalazine (50 mg/kg/day) or 1-hydroxyphthalazine (10 mg/kg/day) to female rabbits caused an increase in… (More)
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