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phosphorothioate

National Institutes of Health

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thiophosphate

Papers overview

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2009
2009
Use of internally nuclease‐protected single‐strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing
Gene editing is potentially a powerful technology for introducing genetic changes by using short single‐stranded DNA… 
Highly Cited
2005
Highly Cited
2005
Genomic sequence correction by single‐stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
Single‐stranded oligonucleotides (ssODN) can induce site‐specific genetic alterations in selected mammalian cells, but the… 
2002
2002
Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties.
Highly Cited
2001
Highly Cited
2001
Amperometric detection of DNA hybridization on a gold surface depends on the orientation of oligonucleotide chains.
Highly Cited
1999
Highly Cited
1999
Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties.
Eighteen peptide-oligonucleotide phosphorothioate conjugates were prepared in good yield and thoroughly characterized with… 
Highly Cited
1994
Highly Cited
1994
Sequence-independent induction of Sp1 transcription factor activity by phosphorothioate oligodeoxynucleotides.
Modified analogues of antisense oligodeoxynucleotides (ODNs), particularly phosphorothioates ([S]ODNs), have been extensively… 
Highly Cited
1991
Highly Cited
1991
Interaction of Escherichia coli tRNA(Ser) with its cognate aminoacyl-tRNA synthetase as determined by footprinting with phosphorothioate-containing tRNA transcripts.
A footprinting technique using phosphorothioate-containing RNA transcripts has been developed and applied to identify contacts… 
Highly Cited
1990
Highly Cited
1990
Stereochemical course of the reaction catalyzed by guanylate cyclase from bovine retinal rod outer segments.
Highly Cited
1984
Highly Cited
1984
Immunoglobulin recognition of synthetic and natural left-handed Z DNA conformations and sequences.
Highly Cited
1979
Highly Cited
1979
Synthesis and enzymatic properties of deoxyribooligonucleotides containing methyl and phenylphosphonate linkages.
Chemical methods for the synthesis of short deoxyribooligonucleotides containing methyl and phenylphosphonodiester linkages have… 
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