phosphorothioate

 
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
In the Drosophila and mammalian RNA interference (RNAi) pathways, target RNA destruction is catalyzed by the siRNA-guided, RNA… (More)
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Highly Cited
2003
Highly Cited
2003
Locked nucleic acids (LNAs) and double-stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for… (More)
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Highly Cited
2002
Highly Cited
2002
The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied… (More)
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2001
2001
Phosphorothioate (PS) oligodeoxynucleotides represent the class of antisense drugs most advanced in development and clinical… (More)
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2000
2000
Macrophages respond to unmethylated CpG motifs present in nonmammalian DNA. Stabilized phosphorothioate-modified… (More)
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2000
2000
Phosphorothioate substitution-interference experiments, routinely used to stereospecifically identify phosphoryl oxygen sites… (More)
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Highly Cited
1996
Highly Cited
1996
Substantial evidence exists supporting a direct role for raf kinases in the development and maintenance of certain human… (More)
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Highly Cited
1995
Highly Cited
1995
An enhanced appreciation of uptake mechanisms and intracellular trafficking of phosphorothioate modified oligodeoxynucleotides (P… (More)
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Review
1993
Review
1993
Because of the specificity of Watson-Crick base pairing, attempts are now being made to use oligodeoxynucleotides (oligos) in the… (More)
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Highly Cited
1990
Highly Cited
1990
Antisense oligodeoxynucleotides specific for sequences in mRNAs from the B-cell lymphoma/leukemia-2 (BCL2) gene were used to… (More)
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