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phosphomannopentaose sulfate

A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia… 
National Institutes of Health

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2 relations

Broader (1)

Oligosaccharides

Narrower (1)

PI-88

Papers overview

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2018
2018
Structural and conformational studies of the heparan sulfate mimetic PI-88
The heparan sulfate mimetic PI-88 is a complex mixture of sulfated oligosaccharides with anti-metastatic and anti-angiogenic… 
2012
2012
Phosphomannopentaose sulfate (PI-88) suppresses angiogenesis by downregulating heparanase and vascular endothelial growth factor in an oxygen-induced retinal neovascularization animal model
Purpose Vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen, and has been associated with… 
2012
2012
Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.
PURPOSE Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the… 
2010
2010
Retinal heparanase expression in streptozotocin-induced diabetic rats.
OBJECTIVE Heparanase, an endoglycosidase, exhibits strong proangiogenic capacity that can induce vascular endothelial growth… 
Review
2008
Review
2008
Targeting heparan sulfate proteoglycans in breast cancer treatment.
Breast carcinoma is one of the leading causes of mortality among female cancers globally. Heparan sulfate proteoglycans, found… 
Review
2008
Review
2008
[The preliminary study of Phosphomannopentaose sulfate (PI-88) on the experimental choroidal neovascularization].
OBJECTIVE To probe the intervention and mechanism of the inhibitor of heparanase (PI-88) on the experimental CNV model… 
Review
2006
Review
2006
Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies.
The sulfated oligosaccharide PI-88 is a potent antiangiogenic, antitumor and anti-metastatic agent derived from yeast. It is… 
Highly Cited
2003
Highly Cited
2003
Blockade of Vascular Smooth Muscle Cell Proliferation and Intimal Thickening After Balloon Injury by the Sulfated Oligosaccharide PI-88: Phosphomannopentaose Sulfate Directly Binds FGF-2, Blocks…
Abstract— Percutaneous transluminal coronary angioplasty is a frequently used interventional technique to reopen arteries that… 
2001
2001
Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides.
1999
1999
Angiogenesis and Heparanase Activity Assays for in Vitro Tumor Growth and Metastasis Using Novel Identification of Sulfated Oligosaccharide-based Inhibitors of Updated Version
Inhibitors of tumor angiogenesis and metastasis are rapidly emerging as important new drug candidates for cancer therapy. To… 
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