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PI-88

Known as: PI 88, heparanase inhibitor PI-88, PI88 cpd 
A sulfated oligosaccharide. PI-88 inhibits heparanase activity and heparan sulfate binding to fibroblast growth factor (FGF) and vascular endothelial… 
National Institutes of Health

Related topics

Related topics

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Broader (1)

phosphomannopentaose sulfate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Discovery of novel sulfonated small molecules that inhibit vascular tube formation.
2012
2012
Phosphomannopentaose sulfate (PI-88) suppresses angiogenesis by downregulating heparanase and vascular endothelial growth factor in an oxygen-induced retinal neovascularization animal model
Purpose Vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen, and has been associated with… 
2007
2007
Heparanase Expression and Function During Early Pregnancy in Mice1
Abstract Embryo implantation is a complex process that involves interactions between cell-surface and extracellular components of… 
2007
2007
In Vivo and in Vitro Degradation of Heparan Sulfate (HS) Proteoglycans by HPR1 in Pancreatic Adenocarcinomas
Heparan sulfate proteoglycans (HSPGs) function as a co-receptor for heparin-binding growth factors, such as fibroblast growth… 
2006
2006
Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides
ABSTRACT A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental… 
Highly Cited
2003
Highly Cited
2003
Probing the interactions of phosphosulfomannans with angiogenic growth factors by surface plasmon resonance.
The binding interactions of the phosphosulfomannan anticancer agent PI-88 (1) with the angiogenic growth factors FGF-1, FGF-2… 
2003
2003
A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances.
The chicken chorioallantoic membrane (CAM) has been extensively used in the study of angiogenesis. However, the CAM assay can be… 
2003
2003
The development of the novel angiogenesis inhibitor PI-88 as an anticancer drug
The novel sulfated oligosaccharide agent PI-88 is being developed by the Australian biotechnology company, Progen Industries… 
2002
2002
Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.
2001
2001
Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides.
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