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PI-88

Known as: PI 88, heparanase inhibitor PI-88, PI88 cpd 
A sulfated oligosaccharide. PI-88 inhibits heparanase activity and heparan sulfate binding to fibroblast growth factor (FGF) and vascular endothelial… 
National Institutes of Health

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Broader (1)

phosphomannopentaose sulfate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Discovery of novel sulfonated small molecules that inhibit vascular tube formation.
2012
2012
Phosphomannopentaose sulfate (PI-88) suppresses angiogenesis by downregulating heparanase and vascular endothelial growth factor in an oxygen-induced retinal neovascularization animal model
Purpose Vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen, and has been associated with… 
2008
2008
Sequential one-pot glycosidations catalytically promoted: unprecedented strategy in oligosaccharide synthesis for the straightforward assemblage of the antitumor PI-88 pentasaccharide.
The pentasaccharide sequence of the most active components of the antitumor drug PI-88, currently in phase II clinical trial, has… 
2006
2006
Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides
ABSTRACT A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental… 
2004
2004
The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448.
Review
2003
Review
2003
Synthetic oligosaccharides as heparin-mimetics displaying anticoagulant properties.
Heparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep… 
Highly Cited
2003
Highly Cited
2003
Probing the interactions of phosphosulfomannans with angiogenic growth factors by surface plasmon resonance.
The binding interactions of the phosphosulfomannan anticancer agent PI-88 (1) with the angiogenic growth factors FGF-1, FGF-2… 
2002
2002
Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC.
2001
2001
Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides.
2001
2001
Anticoagulant and Antiprotease Profiles of a Novel Natural Heparinomimetic Mannopentaose Phosphate Sulfate (PI-88)
Heparinomimetic mannopentaose phosphate sulfate (PI-88) (Progen Industries Ltd. Brisbane, Australia), currently developed as an… 
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