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phosphatidylinositol biosynthetic process

Known as: phosphatidylinositol anabolism, phosphatidylinositol formation, phosphatidylinositol synthesis 
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate… Expand
National Institutes of Health

Papers overview

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2015
2015
Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth.
myo-Inositol is a building block for all inositol-containing phospholipids in eukaryotes. It can be synthesized de novo from… Expand
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2012
2012
Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway.
Posttranslational protein modification by the ubiquitin-like SUMO protein is critical to eukaryotic cell regulation, but much… Expand
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2011
2011
Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.
UNLABELLED Hepatic steatosis is the initial stage of nonalcoholic fatty liver disease (NAFLD) and may predispose to more severe… Expand
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Highly Cited
1997
Highly Cited
1997
The Role of CDP-Diacylglycerol Synthetase and Phosphatidylinositol Synthase Activity Levels in the Regulation of Cellular Phosphatidylinositol Content*
The regulation of phosphatidylinositol synthesis was examined by cloning and expressing in COS-7 cells the human cDNAs encoding… Expand
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1995
1995
Arachidonoyl-diacylglycerol Kinase SPECIFIC IN VITRO INHIBITION BY POLYPHOSPHOINOSITIDES SUGGESTS A MECHANISM FOR REGULATION OF PHOSPHATIDYLINOSITOL BIOSYNTHESIS (*)
We previously described the purification of a membrane-bound diacylglycerol kinase highly selective for sn-1-acyl-2-arachidonoyl… Expand
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Highly Cited
1993
Highly Cited
1993
SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast
Mutations in the SAC1 gene exhibit allele-specific genetic interactions with yeast actin structural gene defects and effect a… Expand
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Highly Cited
1993
Highly Cited
1993
Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.
Trypanosomatid parasites of the genus Leishmania cause a spectrum of widespread tropical diseases. In the vertebrate host they… Expand
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1991
1991
Defective glycosyl phosphatidylinositol biosynthesis in extracts of three Thy-1 negative lymphoma cell mutants.
The glycosyl phosphatidylinositol (GPI) anchors that attach certain proteins to membranes are preassembled by sequential addition… Expand
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1982
1982
myo-Inositol action on gerbil intestine. Association of phosphatidylinositol metabolism with lipid clearance.
The synthesis and turnover of phosphatidylinositol as well as clearance were studied in the intestines of lipodystrophic gerbils… Expand
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1979
1979
Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine.
The incorporation of [32P]Pi into all salivary-gland phospholipids except phosphatidic acid was inhibited by 5-hydroxytryptamine… Expand
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