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phosphatidylinositol biosynthetic process

Known as: phosphatidylinositol anabolism, phosphatidylinositol formation, phosphatidylinositol synthesis 
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt‐deficient zebrafish
Hepatic steatosis is the initial stage of nonalcoholic fatty liver disease (NAFLD) and may predispose to more severe hepatic… Expand
Highly Cited
2010
Highly Cited
2010
Coordination of Storage Lipid Synthesis and Membrane Biogenesis
Despite the importance of triacylglycerols (TAG) and steryl esters (SE) in phospholipid synthesis in cells transitioning from… Expand
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Highly Cited
1997
Highly Cited
1997
The Role of CDP-Diacylglycerol Synthetase and Phosphatidylinositol Synthase Activity Levels in the Regulation of Cellular Phosphatidylinositol Content*
The regulation of phosphatidylinositol synthesis was examined by cloning and expressing in COS-7 cells the human cDNAs encoding… Expand
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1995
1995
Arachidonoyl-diacylglycerol Kinase SPECIFIC IN VITRO INHIBITION BY POLYPHOSPHOINOSITIDES SUGGESTS A MECHANISM FOR REGULATION OF PHOSPHATIDYLINOSITOL BIOSYNTHESIS (*)
We previously described the purification of a membrane-bound diacylglycerol kinase highly selective for sn-1-acyl-2-arachidonoyl… Expand
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Highly Cited
1993
Highly Cited
1993
SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast
Mutations in the SAC1 gene exhibit allele-specific genetic interactions with yeast actin structural gene defects and effect a… Expand
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Highly Cited
1993
Highly Cited
1993
Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.
Trypanosomatid parasites of the genus Leishmania cause a spectrum of widespread tropical diseases. In the vertebrate host they… Expand
Highly Cited
1991
Highly Cited
1991
Defective glycosyl phosphatidylinositol biosynthesis in extracts of three Thy-1 negative lymphoma cell mutants.
The glycosyl phosphatidylinositol (GPI) anchors that attach certain proteins to membranes are preassembled by sequential addition… Expand
1982
1982
Effect of unsaturated fatty acids and Ca2+ on phosphatidylinositol synthesis and breakdown.
CDP-diglyceride : inositol transferase was inhibited by unsaturated fatty acids. The inhibitory activity decreased in the… Expand
1980
1980
Enzymes of phospholipid synthesis: Axonal versus schwann cell distribution
Using quantitative EM autoradiography to localize sites of incorporation of tritiated inositol and choline into mouse sciatic… Expand
Highly Cited
1979
Highly Cited
1979
Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine.
The incorporation of [32P]Pi into all salivary-gland phospholipids except phosphatidic acid was inhibited by 5-hydroxytryptamine… Expand
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