• Publications
  • Influence
The versatility and universality of calcium signalling
TLDR
The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
Inositol trisphosphate and calcium signalling
Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties
Calcium: Calcium signalling: dynamics, homeostasis and remodelling
TLDR
The Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics and has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
Inositol trisphosphate, a novel second messenger in cellular signal transduction
TLDR
Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
Capacitative calcium entry.
  • M. Berridge
  • Biology
    The Biochemical journal
  • 15 November 1995
TLDR
Evidence that the entry of external calcium is somehow controlled by the calcium content of the ER is indicated by incubating cells in Ca2+-free conditions.
Inositol phosphates and cell signalling
TLDR
The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
Elementary and global aspects of calcium signalling.
  • M. Berridge
  • Biology
    The Journal of experimental biology
  • 1 March 1997
TLDR
Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca 2+ signals that regulate cellular activity.
Calcium - a life and death signal
TLDR
This research investigates how the calcium ion regulates cell birth, life and death, and how it regulates so many different cellular processes in the human body.
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