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phosphatidylinositol 3-kinase signaling

Known as: phosphatidylinositol 3-kinase cascade, PI3K signal transduction, PI3K signaling 
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface… 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
RGS16 Inhibits Breast Cancer Cell Growth by Mitigating Phosphatidylinositol 3-Kinase Signaling*
Aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway supports growth of many tumors including those of breast… 
Highly Cited
2008
Highly Cited
2008
Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells
Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into adipocytes in the presence of a hormone… 
Highly Cited
2007
Highly Cited
2007
Basal B Cell Receptor-Directed Phosphatidylinositol 3-Kinase Signaling Turns Off RAGs and Promotes B Cell-Positive Selection1
PI3K plays key roles in cell growth, differentiation, and survival by generating the second messenger phosphatidylinositol-(3,4,5… 
Highly Cited
2006
Highly Cited
2006
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade
Highly Cited
2006
Highly Cited
2006
CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts*
CCN2 is induced by transforming growth factor-β (TGFβ) in fibroblasts and is overexpressed in connective tissue disease. CCN2 has… 
Highly Cited
2002
Highly Cited
2002
Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β*
Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor… 
Highly Cited
2002
Highly Cited
2002
TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor
ABSTRACT We report the characterization of two signal transduction proteins related to Bam32, known as TAPP1 and TAPP2. Bam32… 
Highly Cited
2001
Highly Cited
2001
The Classical Progesterone Receptor Associates with p42 MAPK and Is Involved in Phosphatidylinositol 3-Kinase Signaling inXenopus Oocytes*
The induction of Xenopus laevis oocyte maturation by progesterone is a striking example of a steroid hormone-mediated event that… 
Highly Cited
1998
Highly Cited
1998
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function.
Although it is known that many stimuli can activate mitogen-activated protein kinases (MAPKs) and phosphatidylinositol 3-kinases… 
Highly Cited
1996
Highly Cited
1996
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
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