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Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis
TLDR
It is shown that PGE2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (G protein)–coupled receptor, EP2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase Akt and relieving the inhibitory phosphorylation of β-catenin and activating its signaling pathway. Expand
Narrative Review: The Systemic Capillary Leak Syndrome
TLDR
Clinicians should consider the diagnosis in patients with unexplained edema, increased hematocrit, and hypotension, and patients who survive an initial severe SCLS episode are estimated to have a 10-year survival rate greater than 70%. Expand
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family
TLDR
Introducing RGS family members into yeast blunts signal transduction through the pheromone-response pathway and markedly impair MAP kinase activation by mammalian G-protein-linked receptors, indicating the existence and importance of an SST2-like desensitization mechanism in mammalian cells. Expand
RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits
TLDR
It is reported that RGS9,10 (for regulator of G-protein signalling) proteins are GAPs for Gα subunits, and these RGS proteins are likely to regulate a subset of the G- protein signalling pathways in mammalian cells. Expand
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).
TLDR
A model of SCLS pathogenesis in which nonimmunoglobulin humoral factors such as VEGF and Ang2 contribute to transient endothelial contraction is supported, suggesting a molecular mechanism for this highly lethal disorder. Expand
Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
TLDR
The ability to display ECV maps in units that are physiologically intuitive and may be interpreted on an absolute scale offers the potential for detection of diffuse disease and measurement of the extent and severity of abnormal regions. Expand
RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.
TLDR
It is reported that RGS (for regulator of G-protein signalling) proteins are GAPs for G alpha subunits, and these RGS proteins are likely to regulate a subset of the G- protein signalling pathways in mammalian cells. Expand
R4 RGS proteins: regulation of G-protein signaling and beyond.
TLDR
This review highlights recent advances in the understanding of the physiological functions of one subfamily of RGS proteins with a high degree of homology (B/R4) gleaned from recent studies of knockout mice or cells with reduced RGS expression. Expand
Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation
TLDR
It is suggested that RGS16 may regulate T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR4, CCR3, and CCR5, but not CCR2 or CCR7. Expand
Follicular Dendritic Cell Regulation of CXCR4-Mediated Germinal Center CD4 T Cell Migration1
TLDR
GC T cell nonresponsiveness to CXCL12 correlated with high ex vivo expression of regulator of G protein signaling (RGS), RGS13 and RGS16, mRNA and expression of protein in vivo, and FDCs appear to directly affect GC T cell migration within lymphoid follicles. Expand
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