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phosphatidylinositol 3-kinase complex
Known as:
phosphatidylinositol 3-kinase complex location
, phosphoinositide 3-kinase complex location
, PI3K complex
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A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These…
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National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (2)
PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
PIK3CA-PIK3R1 complex
Broader (1)
extrinsic component of membrane
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
Å. Birgisdottir
,
S. Mouilleron
,
+9 authors
T. Johansen
Autophagy
2019
Corpus ID: 73450673
ABSTRACT Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes…
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2019
2019
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I
Cefan Zhou
,
Xuehong Qian
,
+12 authors
Jingfeng Tang
Autophagy
2019
Corpus ID: 207939267
ABSTRACT Macroautophagy/autophagy plays key roles in development, oncogenesis, and cardiovascular and metabolic diseases…
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2019
2019
Tlr9 and Beclin 1 Cross-Talk Regulates Muscle AMPK Activation in Exercise
Yang Liu
,
P. Nguyen
,
+14 authors
B. Levine
Nature
2019
Corpus ID: 211089216
The activation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle coordinates systemic metabolic…
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Highly Cited
2014
Highly Cited
2014
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
S. Baskaran
,
L. Carlson
,
+6 authors
J. Hurley
eLife
2014
Corpus ID: 16172693
The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase…
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Highly Cited
2013
Highly Cited
2013
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
Y. Araki
,
W. Ku
,
+5 authors
Y. Ohsumi
Journal of Cell Biology
2013
Corpus ID: 2526688
Atg38 provides a physical linkage between the Vps15–Vps34 and Atg14–Vps30 subcomplexes to facilitate PI3-kinase complex I…
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2013
2013
VMP1 is a new player in the regulation of the autophagy-specific phosphatidylinositol 3-kinase complex activation
Maria I Molejon
,
A. Ropolo
,
M. Vaccaro
Autophagy
2013
Corpus ID: 28399213
We have elucidated a novel mechanism through which the autophagy-specific class III phosphatidylinositol 3-kinase (PtdIns3K…
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Highly Cited
2012
Highly Cited
2012
Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements
M. Zieger
,
A. Mayer
Molecular Biology of the Cell
2012
Corpus ID: 8712213
Yeast vacuoles are large organelles that fragment and fuse in response to environmental conditions, such as changes in osmotic…
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Highly Cited
2001
Highly Cited
2001
Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network
A. Kihara
,
Y. Kabeya
,
Y. Ohsumi
,
T. Yoshimori
EMBO Reports
2001
Corpus ID: 30455781
Autophagy is an intracellular bulk protein degradation system. Beclin is known to be involved in this process; however, its role…
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1996
1996
Binding to the Platelet-derived Growth Factor Receptor Transiently Activates the p85α-p110α Phosphoinositide 3-Kinase Complex in Vivo*
J. Domin
,
R. Dhand
,
M. Waterfield
Journal of Biological Chemistry
1996
Corpus ID: 20475978
Ligand stimulation of the platelet-derived growth factor (PDGF) receptor results in its association with phosphoinositide 3…
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Highly Cited
1992
Highly Cited
1992
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.
I. Gout
,
R. Dhand
,
+4 authors
M. Waterfield
Biochemical Journal
1992
Corpus ID: 25233009
PtdIns 3-kinase associates with certain activated protein-tyrosine kinase receptors and with the pp60c-src/polyoma middle-T…
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