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Guidelines for the use and interpretation of assays for monitoring autophagy
- D. Klionsky, F. Abdalla, +498 authors Shengzhou or sheng-zhou wu
- Medicine, Biology
- 1 April 2012
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
Autophagy fights disease through cellular self-digestion
Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death. Expand
Regulation mechanisms and signaling pathways of autophagy.
The current knowledge on the key genes composing the autophagy machinery in eukaryotes from yeast to mammalian cells and the signaling pathways that sense the status of different types of stress and induce autophagic for cell survival and homeostasis are presented. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented. Expand
Development by self-digestion: molecular mechanisms and biological functions of autophagy.
This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy. Expand
Mammalian autophagy: core molecular machinery and signaling regulation.
Recent advances in identifying and understanding the core molecular machinery and signaling pathways that are involved in mammalian autophagy are highlighted. Expand
A protein conjugation system essential for autophagy
It is shown here that a unique covalent-modification system is essential for autophagy to occur, the first report of a protein unrelated to ubiquitin that uses a ubiquitination-like conjugation system. Expand
Autophagosome formation: core machinery and adaptations
A core molecular machinery has a critical role in forming sequestering vesicles, the autophagosome, which is the hallmark morphological feature of this dynamic process. Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- L. Galluzzi, I. Vitale, +166 authors G. Kroemer
- Biology, Medicine
- Cell Death & Differentiation
- 23 January 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed. Expand
Autophagy: from phenomenology to molecular understanding in less than a decade
- D. Klionsky
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 November 2007
In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis,” and this statement turned out to be prophetic, and this process of 'self-eating' rapidly exploded as a research field, as scientists discovered connections to cancer, neurodegeneration and even lifespan extension. Expand