phorboxazole A

The phorboxazole natural products are among the most potent inhibitors of cancer cell division, but they are essentially… (More)

The phorboxazoles are mixed non-ribosomal peptide synthase/polyketide synthase biosynthetic products that embody polyketide… (More)

Hemi-phorboxazole A, a minor truncated analogue of phorboxazole A from the marine sponge Phorbas sp., was isolated in a total… (More)

[Structure: see text] Subunits of phorboxazole A containing C1-C2, C3-C8, C9-C19, C20-C32, C33-C41, and C42-C46 were connected in… (More)

[Structure: see text] Four subunits of the potent antitumor agent phorboxazole A were constructed; fragments C20-C32 and C9-C19… (More)

[Structure: see text] Described is a regio- and stereoselective ring-closing metathesis (RCM) to form the C2-C3 alkene of the… (More)

To enable studies to elucidate the intracellular processing and targeting of the potent cytostatic/apoptotic anticancer natural… (More)

The C46 terminus of phorboxazole A has been modified to incorporate a biotin-terminated linker via direct palladium-mediated… (More)

A convergent total synthesis of phorboxazole A (1a), from the C(3-19), C(20-27) and C(33-46) fragments 5, 4 and 91, respectively… (More)

A highly convergent, stereocontrolled total synthesis of the potent antiproliferative agent (+)phorboxazole A (1) has been… (More)