Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues.

@article{Smith2011PhorboxazoleSS,
  title={Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues.},
  author={Amos B. Smith and Anne-Marie L. Hogan and Zhuqing Liu and Thomas M Razler and Regina M. Meis and B. Morinaka and T. Molinski},
  journal={Tetrahedron},
  year={2011},
  volume={67 27-28},
  pages={
          5069-5078
        }
}
The design, synthesis and biological evaluation of a new phorboxazole analogue, comprising an acetal replacement for the C-ring tetrahdropyran of the natural product and carrying a potency-enhancing C(45-46) vinyl chloride side chain, is described. In addition, the synthesis of (+)-hemi-phorboxazole A and a series of related hemi-phorboxazole A analogues has been achieved. The new acetal ring replacement analogue displayed activity comparable to that of the parent natural product against HCT… Expand
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