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phenylalanine 4-monooxygenase activity
Known as:
phenylalaninase activity
, L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
, PAH activity
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Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. [EC:1.14.16.1]
National Institutes of Health
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Phenylalanine Hydroxylase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
The mycotoxin ochratoxin A is a substrate for phenylalanine hydroxylase in isolated rat hepatocytes and in vivo
E. Creppy
,
K. Chakor
,
M. J. Fisher
,
G. Dirheimer
Archives of Toxicology
2005
Corpus ID: 9746966
Ochratoxin A (OTA), is a mycotoxin contaminating food and feed stuffs, consisting of a chlorinated dihydroisocoumarin linked…
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1994
1994
Phenylalanine Kinetics in Sick Preterm Neonates with Respiratory Distress Syndrome
G. Shortland
,
J. Walter
,
P. Fleming
,
D. Halliday
Pediatric Research
1994
Corpus ID: 25616943
ABSTRACT: The cause of hyperphenylalaninemia in sick preterm infants has yet to be determined; one reason may be reduced…
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Highly Cited
1977
Highly Cited
1977
Atypical phenylketonuria with normal phenylalanine hydroxylase and dihydropteridine reductase activity in vitro.
K. Bartholomé
,
D. Byrd
,
S. Kaufman
,
S. Milstien
Pediatrics
1977
Corpus ID: 33546241
A child with phenylketonuria had normal phenylalanine hydroxylase activity in vitro. In addition, all known components of the…
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Highly Cited
1976
Highly Cited
1976
Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats.
O. Greengard
,
M. S. Yoss
,
J. A. del Valle
Science
1976
Corpus ID: 12692250
alpha-Methylphenylalanine reduces the phenylalanine hydroxylase activity of rat liver by 75 percent. Daily injections of this…
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1975
1975
Studies on the phenylalanine hydroxylase system in liver slices.
S. Milstien
,
S. Kaufman
Journal of Biological Chemistry
1975
Corpus ID: 8682061
Highly Cited
1973
Highly Cited
1973
Impairment of phenylalanine hydroxylation in chronic renal insufficiency.
G. Young
,
F. Parsons
Clinical science
1973
Corpus ID: 30250489
1. Plasma tyrosine and phenylalanine were measured in patients with chronic renal failure and in normal subjects. Plasma tyrosine…
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Highly Cited
1973
Highly Cited
1973
Phenylalanine Hydoxylase in Human Liver during Development
N. Räihä
Pediatric Research
1973
Corpus ID: 24837810
Extract: Phenylalanine hydroxylase activity is present in the liver of human fetuses after the 8th week of gestation, and…
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Highly Cited
1972
Highly Cited
1972
The quantitative determination of phenylalanine hydroxylase in rat tissues. Its developmental formation in liver.
M. McGee
,
O. Greengard
,
W. Knox
Biochemical Journal
1972
Corpus ID: 7759341
A sensitive method was developed for determining the phenylalanine hydroxylase activity of crude tissue preparations in the…
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Highly Cited
1967
Highly Cited
1967
A simple radioisotope assay for phenylalanine hydroxylase.
Gordon Guroff
,
Amnon Abramowitz
Analytical Biochemistry
1967
Corpus ID: 41357086
Highly Cited
1962
Highly Cited
1962
Hydroxylation of tryptophan by phenylalanine hydroxylase.
J. Renson
,
H. Weissbach
,
S. Udenfriend
Journal of Biological Chemistry
1962
Corpus ID: 32681503
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