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phenylalanine 4-monooxygenase activity

Known as: phenylalaninase activity, L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating), PAH activity 
Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. [EC:1.14.16.1]
National Institutes of Health

Related topics

Related topics

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Phenylalanine Hydroxylase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
The mycotoxin ochratoxin A is a substrate for phenylalanine hydroxylase in isolated rat hepatocytes and in vivo
Ochratoxin A (OTA), is a mycotoxin contaminating food and feed stuffs, consisting of a chlorinated dihydroisocoumarin linked… 
1994
1994
Phenylalanine Kinetics in Sick Preterm Neonates with Respiratory Distress Syndrome
ABSTRACT: The cause of hyperphenylalaninemia in sick preterm infants has yet to be determined; one reason may be reduced… 
Highly Cited
1977
Highly Cited
1977
Atypical phenylketonuria with normal phenylalanine hydroxylase and dihydropteridine reductase activity in vitro.
A child with phenylketonuria had normal phenylalanine hydroxylase activity in vitro. In addition, all known components of the… 
Highly Cited
1976
Highly Cited
1976
Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats.
alpha-Methylphenylalanine reduces the phenylalanine hydroxylase activity of rat liver by 75 percent. Daily injections of this… 
1975
1975
Studies on the phenylalanine hydroxylase system in liver slices.
Highly Cited
1973
Highly Cited
1973
Impairment of phenylalanine hydroxylation in chronic renal insufficiency.
1. Plasma tyrosine and phenylalanine were measured in patients with chronic renal failure and in normal subjects. Plasma tyrosine… 
Highly Cited
1973
Highly Cited
1973
Phenylalanine Hydoxylase in Human Liver during Development
Extract: Phenylalanine hydroxylase activity is present in the liver of human fetuses after the 8th week of gestation, and… 
Highly Cited
1972
Highly Cited
1972
The quantitative determination of phenylalanine hydroxylase in rat tissues. Its developmental formation in liver.
A sensitive method was developed for determining the phenylalanine hydroxylase activity of crude tissue preparations in the… 
Highly Cited
1967
Highly Cited
1967
A simple radioisotope assay for phenylalanine hydroxylase.
Highly Cited
1962
Highly Cited
1962
Hydroxylation of tryptophan by phenylalanine hydroxylase.
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