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pharmacophore

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Abstract Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts… 
Review
2016
Review
2016
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD… 
Review
2015
Review
2015
Computational methods are well-established tools in the drug discovery process and can be employed for a variety of tasks. Common… 
Highly Cited
2013
Highly Cited
2013
Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2 inhibitors which have different… 
Highly Cited
2011
Highly Cited
2011
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like… 
Review
2010
Review
2010
  • T. Langer
  • Molecular Informatics
  • 2010
  • Corpus ID: 885842
The pharmacophore concept in modern drug research is highlighted and the most important use examples and success stories are… 
Review
2001
Review
2001
Perceiving a pharmacophore is the first essential step towards understanding the interaction between a receptor and a ligand… 
Highly Cited
1997
Highly Cited
1997
Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester (CAPE… 
Highly Cited
1996
Highly Cited
1996
Highly Cited
1988
Highly Cited
1988
The 3-substituted beta-carbolines 2-4 and 5-7 were prepared from 3-amino-beta-carboline (8) in one step via diazotization…