pharmacophore

 
National Institutes of Health

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2015
2015
B-Raf kinase is an important target in treatment of cancers. In order to design and find potent B-Raf inhibitors (BRIs), 3D… (More)
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2015
2015
During the past few years, pharmacophore modeling has become one of the key components in computer-aided drug design and in… (More)
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2013
2013
Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2 inhibitors which have different… (More)
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2013
2013
The Classical Swine Fever virus (CSFV) is a major pathogen of livestock and belongs to the flaviviridae viral family. Even though… (More)
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2012
2012
Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. As a neurotransmitter, serotonin plays important… (More)
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2011
2011
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like… (More)
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2011
2011
Histone deacetylase 8 (HDAC8) is an enzyme involved in deacetylating the amino groups of terminal lysine residues, thereby… (More)
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2009
2009
Histamine H3 receptor (H3R) antagonists have some antipsychotic properties although the clear molecular mechanism is still… (More)
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2000
2000
Molecular modifications of both the kappa opioid antagonist norbinaltorphimine (norBNI, 1) and the kappa receptor have provided… (More)
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1997
1997
Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester (CAPE… (More)
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