pharmacophore
National Institutes of Health
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Abstract Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts…
Heat Shock Protein 90 was a key molecular chaperone involved in the proteome stability maintenance and its interference in many…
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like…
Histone deacetylase 8 (HDAC8) is an enzyme involved in deacetylating the amino groups of terminal lysine residues, thereby…
κM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to…
Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester (CAPE…
A series of 2-(aminomethyl)chromans (2-AMCs) was synthesized and evaluated for their affinity and selectivity for both the high…
In an effort to develop selective antagonists for kappa opioid receptors, bivalent ligands that contain opioid antagonist…