pharmacophore
National Institutes of Health
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Abstract Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts…
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD…
Computational methods are well-established tools in the drug discovery process and can be employed for a variety of tasks. Common…
Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2 inhibitors which have different…
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like…
The pharmacophore concept in modern drug research is highlighted and the most important use examples and success stories are…
Perceiving a pharmacophore is the first essential step towards understanding the interaction between a receptor and a ligand…
Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester (CAPE…
The 3-substituted beta-carbolines 2-4 and 5-7 were prepared from 3-amino-beta-carboline (8) in one step via diazotization…