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pharmacophore

 
National Institutes of Health

Papers overview

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2017
2017
Abstract Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts… Expand
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2015
2015
A series of densely functionalized piperidine (FP) scaffolds was synthesized following a diastereoselective one-pot… Expand
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2013
2013
Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2 inhibitors which have different… Expand
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Highly Cited
2011
Highly Cited
2011
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like… Expand
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2005
2005
κM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to… Expand
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Highly Cited
1997
Highly Cited
1997
Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester (CAPE… Expand
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1997
1997
A series of 2-(aminomethyl)chromans (2-AMCs) was synthesized and evaluated for their affinity and selectivity for both the high… Expand
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Highly Cited
1996
Highly Cited
1996
Germany performs well on many indicators of economic performance and well-being, including unemployment. In contrast, investment… Expand
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Highly Cited
1988
Highly Cited
1988
The 3-substituted beta-carbolines 2-4 and 5-7 were prepared from 3-amino-beta-carboline (8) in one step via diazotization… Expand
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Highly Cited
1988
Highly Cited
1988
In an effort to develop selective antagonists for kappa opioid receptors, bivalent ligands that contain opioid antagonist… Expand
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