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pharmacophore

National Institutes of Health

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Receptors, Drug

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s disease
Abstract Alzheimer’s disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts… 
Review
2016
Review
2016
Computational methods in drug discovery
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD… 
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Review
2015
Review
2015
Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases
Computational methods are well-established tools in the drug discovery process and can be employed for a variety of tasks. Common… 
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2015
2015
In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores.
A series of densely functionalized piperidine (FP) scaffolds was synthesized following a diastereoselective one-pot… 
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2013
2013
Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Discovery of Novel Akt2 Inhibitors
Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2 inhibitors which have different… 
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Highly Cited
2011
Highly Cited
2011
3D QSAR Pharmacophore Modeling, in Silico Screening, and Density Functional Theory (DFT) Approaches for Identification of Human Chymase Inhibitors
Human chymase is a very important target for the treatment of cardiovascular diseases. Using a series of theoretical methods like… 
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Review
2001
Review
2001
Pharmacophore modeling and three-dimensional database searching for drug design using catalyst.
Perceiving a pharmacophore is the first essential step towards understanding the interaction between a receptor and a ligand… 
Highly Cited
1997
Highly Cited
1997
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
Starting from a known inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN); caffeic acid phenethyl ester (CAPE… 
Highly Cited
1996
Highly Cited
1996
Germany
Germany performs well on many indicators of economic performance and well-being, including unemployment. In contrast, investment… 
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Highly Cited
1988
Highly Cited
1988
Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.
The 3-substituted beta-carbolines 2-4 and 5-7 were prepared from 3-amino-beta-carboline (8) in one step via diazotization… 
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