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Pharmacology of nociceptin and its receptor: a novel therapeutic target
TLDR
New advances have contributed to better understanding of the pathophysiological role of the NC/OP4 system, and ultimately will help to identify the therapeutic potential of new OP4 receptor ligands. Expand
Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
TLDR
An exhaustive solvent scan showed a high propensity of Abeta-(1-42) to adopt helical conformations in aqueous solutions of fluorinated alcohols, which suggests a direct mechanism of neurotoxicity in Abeta. Expand
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice
TLDR
The effects of in vivo supraspinal NPS in mice are evaluated and it is shown that in vivo NPS produces a unique behavioural profile by increasing wakefulness and exerting anxiolytic‐like effects. Expand
Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice
TLDR
UFP-101 exhibits pronounced antidepressant-like effects in different species and animal models, possibly by preventing the inhibitory effects of endogenous N/OFQ on brain monoaminergic (in particular serotonergic) neurotransmission. Expand
A new selective antagonist of the nociceptin receptor
TLDR
The present findings indicate that [Phe1Ψ(CH2‐NH)Gly2]NC(1‐13)NH2 is a selective antagonist of the nociceptin receptor. Expand
Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways.
TLDR
It is shown that activation of PAR-2 causes multiple motor effects in these airways, including in vivo bronchoconstriction, which is in part mediated by a neural mechanism. Expand
Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats
TLDR
Findings provide further evidence that selective agonists at the ORL-1 receptor attenuate ethanol intake in alcohol-preferring rats and suggest that the NC/ORL1 system may represent an interesting target for treatment of alcohol abuse. Expand
The Tachykinin Peptide Family
TLDR
An update on the current body of knowledge regarding tachykinin occurrence and distribution in the animal kingdom, from the lowest invertebrates to man, and the physiological and pharmacological actions of tachyKinins outlining the pregnant importance of this large peptide family is provided. Expand
Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.
TLDR
It is indicated that the structural requirements of NC for occupation and activation of its receptor are different from that of opioids, particularly delta agonists. Expand
Blockade of nociceptin/orphanin FQ–NOP receptor signalling produces antidepressant‐like effects: pharmacological and genetic evidences from the mouse forced swimming test
TLDR
Results indicate that blockade of the N/OFQ‐NOP receptor signalling in the brain produces antidepressant‐like effects in the mouse FST, and support the NOP receptor as a candidate target for the development of innovative antidepressant drugs. Expand
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