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perampanel

Known as: Benzonitrile, 2-(1',6'-Dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, Perampanelum 
An orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with… 
National Institutes of Health

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7 relations
AMPA Receptor Antagonists [MoA]perampanel 0.5 MG/ML Oral Suspensionperampanel 10 MG Oral Tabletperampanel 6 MG Oral Tablet

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Pyridones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Tolerability and efficacy of perampanel in children with refractory epilepsy
There are few reports on the tolerability and efficacy of perampanel, a new antiepileptic drug with a novel mechanism of action… 
Review
2017
Review
2017
Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy
Purpose Perampanel is a first-in-class antiepileptic medication approved for the treatment of partial (focal) seizures, and as… 
2016
2016
One-year clinical experience of perampanel in Spain: a multicentre study of efficacy and tolerability.
Perampanel, a non-competitive antagonist of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors, is the most… 
2016
2016
The effects of AMPA blockade on the spectral profile of human early visual cortex recordings studied with non-invasive MEG
Review
2015
Review
2015
Perampanel in the treatment of focal and idiopathic generalized epilepsies and of status epilepticus
Perampanel is the latest approved antiepileptic drug in focal and generalized epilepsies and has a distinct and selective mode of… 
Review
2013
Review
2013
Safety and tolerability of perampanel: a review of clinical trial data
The Phase II and Phase III clinical development program of perampanel is providing a wealth of data on the safety and… 
Review
2013
Review
2013
Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel
Introduction: Complex-partial seizures are frequently resistant to antiepileptic therapy. Two new medications with mechanisms of… 
Review
2013
Review
2013
Efficacy of perampanel: a review of clinical trial data
The efficacy of adjunctive perampanel has been investigated in an extensive clinical development program across a broad… 
2012
2012
Perampanel in Parkinson Disease Fluctuations: A Double-Blind Randomized Trial With Placebo and Entacapone
ObjectivesPerampanel is a selective and noncompetitive &agr;-amino-3-hydroxy-5-methylisoxazole propionic acid–type glutamate… 
2009
2009
Understanding near/far-field engineering of optical dimer antennas through geometry modification.
Numerical investigations based on the boundary element method (BEM) have been carried out to two-dimensional (2-D) silver dimer… 
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