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perampanel
Known as:
Benzonitrile, 2-(1',6'-Dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-
, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
, Perampanelum
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An orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with…
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National Institutes of Health
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7 relations
AMPA Receptor Antagonists [MoA]
perampanel 0.5 MG/ML Oral Suspension
perampanel 10 MG Oral Tablet
perampanel 6 MG Oral Tablet
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Narrower (1)
FYCOMPA
Broader (1)
Pyridones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Mechanisms of action of currently used antiseizure drugs
G. Sills
,
M. Rogawski
Neuropharmacology
2020
Corpus ID: 210220052
Highly Cited
2015
Highly Cited
2015
Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy
J. French
,
G. Krauss
,
+8 authors
F. Bibbiani
Neurology
2015
Corpus ID: 35638747
Objective: To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic…
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Review
2015
Review
2015
The clinical pharmacology profile of the new antiepileptic drug perampanel: A novel noncompetitive AMPA receptor antagonist
P. Patsalos
Epilepsia
2015
Corpus ID: 20444490
The clinical pharmacology profile of a drug critically determines its therapeutics, and this review summarizes the…
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Review
2015
Review
2015
Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)
M. Bialer
,
S. Johannessen
,
R. Levy
,
E. Perucca
,
T. Tomson
,
H. White
Epilepsy Research
2015
Corpus ID: 8416405
Review
2013
Review
2013
Preclinical pharmacology of perampanel, a selective non‐competitive AMPA receptor antagonist
Michael A. Rogawski
,
Takahisa Hanada
Acta Neurologica Scandinavica, Supplementum
2013
Corpus ID: 13832539
Perampanel [2‐(2‐oxo‐1‐phenyl‐5‐pyridin‐2‐yl‐1,2‐dihydropyridin‐3‐yl)benzonitrile; E2007] is a potent, selective, orally active…
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Highly Cited
2013
Highly Cited
2013
Concentration–effect relationships with perampanel in patients with pharmacoresistant partial‐onset seizures
B. Gidal
,
J. Ferry
,
O. Majid
,
Ziad Hussein
Epilepsia
2013
Corpus ID: 7095378
Although there is a general paucity of published pharmacokinetic (PK) data for new antiepileptic drugs (AEDs), PK analyses of…
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Highly Cited
2013
Highly Cited
2013
Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: A pooled analysis of three phase III studies
B. Steinhoff
,
E. Ben-Menachem
,
+7 authors
A. Laurenza
Epilepsia
2013
Corpus ID: 30059341
Three phase III studies (304 [ClinicalTrials.gov identifier: NCT00699972], 305 [NCT00699582], 306 [NCT00700310]) evaluated…
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Highly Cited
2012
Highly Cited
2012
Adjunctive perampanel for refractory partial-onset seizures
G. L. Krauss
,
J. Serratosa
,
+8 authors
A. Laurenza
2012
Corpus ID: 31306962
Objective: To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1–3 concomitant antiepileptic drugs…
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Highly Cited
2011
Highly Cited
2011
Perampanel: A novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy
Takahisa Hanada
,
Yutaka Hashizume
,
+7 authors
Y. Nishizawa
Epilepsia
2011
Corpus ID: 21529777
Purpose: To assess the pharmacology of perampanel and its antiseizure activity in preclinical models. Perampanel [2‐(2‐oxo‐1…
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Highly Cited
2009
Highly Cited
2009
In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy.
Liping Xu
,
F. Pan
,
Guoning Yu
,
Lei Yang
,
E. Zhang
,
Ke Yang
Biomaterials
2009
Corpus ID: 32737207
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