perampanel

Known as: Benzonitrile, 2-(1',6'-Dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, Perampanelum 
An orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
OBJECTIVE To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE To assess the efficacy and safety of once-daily doses of perampanel 8 and 12 mg when added to 1-3 concomitantly… (More)
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Review
2013
Review
2013
Perampanel [2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile; E2007] is a potent, selective, orally active… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Three phase III studies (304 [ClinicalTrials.gov identifier: NCT00699972], 305 [NCT00699582], 306 [NCT00700310… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVE To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVE To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1-3 concomitant antiepileptic drugs (AEDs… (More)
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2012
2012
OBJECTIVES To evaluate, for the first time in patients with epilepsy, the tolerability and safety of escalating doses of oral… (More)
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2012
2012
OBJECTIVES Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE To assess the pharmacology of perampanel and its antiseizure activity in preclinical models. Perampanel [2-(2-oxo-1… (More)
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Highly Cited
2009
Highly Cited
2009
Magnesium has shown potential application as a bio-absorbable biomaterial, such as for bone screws and plates. In order to… (More)
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