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Postictal generalized electroencephalographic suppression is associated with generalized seizures
Postictal generalized electroencephalographic suppression (PGES) may be involved in sudden unexpected death in epilepsy (SUDEP). We examined whether the occurrence of PGES depends on seizure type andExpand
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Cost of epilepsy: a systematic review.
The objective of this review was to overview published cost-of-illness (COI) studies of epilepsy and their methodological approaches. Epilepsy imposes a substantial burden on individuals and societyExpand
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KCNC3: phenotype, mutations, channel biophysics—a study of 260 familial ataxia patients
We recently identified KCNC3, encoding the Kv3.3 voltage‐gated potassium channel, as the gene mutated in SCA13. One g.10684G>A (p.Arg420His) mutation caused late‐onset ataxia resulting in aExpand
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The LaLiMo Trial: lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsy—an open-label, prospective, randomised controlled multicenter study
Background Of the newer antiepileptic drugs, lamotrigine (LTG) and levetiracetam (LEV) are popular first choice drugs for epilepsy. The authors compared these drugs with regard to their efficacy andExpand
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Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany—a nationwide population-based study in children and adults
Nationwide analyses of drug use can provide a prevalence estimate of the underlying disease and can help in understanding the characteristics of treatment. This study aimed for such analysesExpand
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Intravenous initiation and maintenance of ketogenic diet: Proof of concept in super-refractory status epilepticus
Super-refractory status epilepticus (SE) is characterized by unresponsiveness to initial anaesthetic therapy. This definition encompasses a SE that continues or recurs 24 h or more after the onset ofExpand
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Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15
Growth/differentiation factor-15 (GDF-15) is a widely expressed distant member of the TGF-β superfamily with prominent neurotrophic effects on midbrain dopaminergic neurons. We show here thatExpand
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Management and long‐term outcome in patients presenting with ictal asystole or bradycardia
Purpose:  Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life‐threatening. Guidelines for the care of these patients areExpand
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Postmarketing experience with brivaracetam in the treatment of epilepsies: A multicenter cohort study from Germany
To evaluate factors predicting efficacy, retention, and tolerability of add‐on brivaracetam (BRV) in clinical practice.
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Postictal increase in T‐wave alternans after generalized tonic–clonic seizures
Purpose:  Sudden unexpected death in epilepsy (SUDEP) occurs most frequently in people with chronic uncontrolled epilepsy. Tonic–clonic seizures are a well‐recognized risk factor for SUDEP. T‐waveExpand
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