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pemirolast

Known as: PERMIROLAST, 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one, pemirolast [Chemical/Ingredient] 
A pyrimidinone derivative with anti-allergic activity. Pemirolast blocks the antigen-mediated calcium ion influx into mast cells. This prevents mast… 
National Institutes of Health

Related topics

Related topics

7 relations
Allergic ConjunctivitisCalcium Channel Antagonists [MoA]

Narrower (2)

BMY 26517Pemirolast potassium

Broader (3)

Histamine AntagonistsPyridinesPyrimidinones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Randomized clinical trial of mast cell inhibition in patients with a medium‐sized abdominal aortic aneurysm
2003
2003
A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.
2000
2000
(9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis.
1997
1997
Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract.
1994
1994
Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils.
To determine whether pemirolast, a new antiallergic drug, inhibits the activation of eosinophils, we investigated the effect of… 
1993
1993
Effects of quinotolast, a new orally active antiallergic drug, on experimental allergic models.
The effects of a new antiallergic drug, quinotolast [sodium 5-(4-oxo-1-phenoxy-4H-quinolizine-3-carboxamido)tetrazolate… 
1992
1992
Inhibition of radiolabeled leukotriene-binding by AS-35 in guinea pig lung membrane fraction.
The inhibitory effects of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one… 
1992
1992
Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug.
The effects of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (AS-35), a… 
1991
1991
A pilot study of pemirolast in patients with seasonal allergic rhinitis.
Pemirolast is a potent, long-acting, orally effective antiallergic agent evaluated for clinical activity in prevention of… 
1987
1987
Liquid chromatographic determination of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one in human plasma with fluorescence detection.
A simple and sensitive assay for quantitating 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (1; BMY 26517) in… 
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