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pbx1 protein, human

Known as: pre-B-cell leukemia homeobox 1 protein, human, PBX1, pbx1 proto-oncogene protein, human 
Pre-B-cell leukemia transcription factor 1 (430 aa, ~47 kDa) is encoded by the human PBX1 gene. This protein plays a role in the regulation of… 
National Institutes of Health

Related topics

Related topics

8 relations
DNA-Binding ProteinsGenes, RegulatorHomeodomain ProteinsPBX1 gene

Broader (1)

Proto-Oncogene Proteins

Papers overview

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Highly Cited
2011
Highly Cited
2011
PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer
Altered transcriptional programs are a hallmark of diseases, yet how these are established is still ill-defined. PBX1 is a TALE… 
Highly Cited
2009
Highly Cited
2009
KLF4 and PBX1 Directly Regulate NANOG Expression in Human Embryonic Stem Cells
Insight into the regulation of core transcription factors is important for a better understanding of the molecular mechanisms… 
Highly Cited
2006
Highly Cited
2006
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression
Vertebrate limb development occurs along three cardinal axes–proximodistal, anteroposterior and dorsoventral–that are established… 
Highly Cited
2002
Highly Cited
2002
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
Pbx1 is a member of the TALE (three–amino acid loop extension) class of homeodomain transcription factors, which are components… 
Highly Cited
2001
Highly Cited
2001
The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.
Pbx1 is the product of a proto-oncogene originally discovered at the site of chromosomal translocations in acute leukemias. It… 
Highly Cited
1999
Highly Cited
1999
The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH.
Nuclear localization of the Extradenticle (EXD) and PBX1 proteins is regionally restricted during Drosophila and mammalian… 
Highly Cited
1997
Highly Cited
1997
A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1.
Pbx1 is a homeodomain transcription factor that has the ability to form heterodimers with homeodomain proteins encoded by the… 
Highly Cited
1997
Highly Cited
1997
Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1.
E2a-Pbx1 is a chimeric transcription factor oncoprotein produced by the t(1;19) translocation in human pre-B cell leukemia. Class… 
Highly Cited
1995
Highly Cited
1995
Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes
E2A-PBX1 is the oncogene produced at the t(1;19) chromosomal breakpoint of pediatric pre-B-cell leukemia. Expression of E2A-Pbx1… 
Highly Cited
1991
Highly Cited
1991
PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
Two new homeobox genes, PBX2 and PBX3, were isolated on the basis of their extensive homology to PBX1, a novel human homeobox… 
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