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FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Complex organisms require tissue-specific transcriptional programs, yet little is known about how these are established. The transcription factor FoxA1 is thought to contribute to gene regulation… Expand
Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer
The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent marks its lethal progression. The androgen receptor (AR) is essential in both, though its… Expand
Nucleosome Dynamics Define Transcriptional Enhancers
Chromatin plays a central role in eukaryotic gene regulation. We performed genome-wide mapping of epigenetically marked nucleosomes to determine their position both near transcription start sites and… Expand
Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
- S. Setlur, K. D. Mertz, +23 authors M. Rubin
- Biology, Medicine
- Journal of the National Cancer Institute
- 4 June 2008
BACKGROUND The majority of prostate cancers harbor gene fusions of the 5'-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast… Expand
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression
- Richard Cowper-Sal·lari, X. Zhang, +5 authors M. Lupien
- Medicine, Biology
- Nature Genetics
- 30 August 2012
Genome-wide association studies (GWAS) have identified thousands of SNPs that are associated with human traits and diseases. But, because the vast majority of these SNPs are located in non-coding… Expand
Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
DNA variants (SNPs) that predispose to common traits often localize within noncoding regulatory elements such as enhancers. Moreover, loci identified by genome-wide association studies (GWAS) often… Expand
Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.
The transcription factor GATA-3 is required for normal mammary gland development, and its expression is highly correlated with estrogen receptor alpha (ER alpha) in human breast tumors. However, the… Expand
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but… Expand
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.
Estrogen receptor alpha (ER alpha) mediates breast cancer proliferation through transcriptional mechanisms involving the recruitment of specific coregulator complexes to the promoters of cell cycle… Expand
Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor α Expression in Breast Cancer
The transcription factor GATA-3 is required for normal mammary gland development, and its expression is highly correlated with estrogen receptor α (ERα) in human breast tumors. However, the… Expand