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pamapimod

National Institutes of Health

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Broader (2)

PyridonesPyrimidines

Papers overview

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2011
2011
Metabolism and excretion of a novel p38 MAP kinase inhibitor pamapimod in healthy male subjects.
OBJECTIVE This study investigated the pharmacokinetics, excretion, and metabolism of pamapimod following a single oral dose in… 
2010
2010
Differential effects of p38MAP kinase inhibitors on the expression of inflammation‐associated genes in primary, interleukin‐1β‐stimulated human chondrocytes
Background and purpose:  A main challenge in the therapy of osteoarthritis (OA) is the development of drugs that will modify the… 
2010
2010
A Proof‐of‐Concept and Drug‐Drug Interaction Study of Pamapimod, a Novel p38 MAP Kinase Inhibitor, With Methotrexate in Patients With Rheumatoid Arthritis
This study evaluated the potential pharmacokinetic interaction of pamapimod, a p38 mitogen‐activated protein kinase inhibitor… 
Review
2010
Review
2010
Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?
Methotrexate alone or in combination with other agents is the standard treatment for moderate-to-severe rheumatoid arthritis. As… 
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