p21 N-Ras Protein

Known as: Proto-Oncogene Protein p21(c-N-ras), p21(N-ras), N-Ras Protein 
p21 N-RAS protein is encoded by the N-RAS gene. RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2017
0204019842017

Papers overview

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Highly Cited
2013
Highly Cited
2013
Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although… (More)
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2013
2013
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we… (More)
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Highly Cited
2012
Highly Cited
2012
Recent results from clinical trials with the BRAF inhibitors GSK2118436 (dabrafenib) and PLX4032 (vemurafenib) have shown… (More)
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Highly Cited
2010
Highly Cited
2010
BRAF(V600E/K) is a frequent mutationally active tumor-specific kinase in melanomas that is currently targeted for therapy by the… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE: Activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway has been implicated in melanoma based primarily on the… (More)
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Highly Cited
2007
Highly Cited
2007
We have identified one frameshift mutation, one splice-site mutation, and two missense mutations in highly conserved residues in… (More)
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2006
2006
Activating mutations in RAS, predominantly NRAS, are common in myeloid malignancies. Previous studies in animal models have shown… (More)
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Highly Cited
2005
Highly Cited
2005
Palmitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment… (More)
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2005
2005
The majority of human melanomas harbor activating mutations in either the BRAF or NRAS gene. To date, the role of oncogenic NRAS… (More)
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Highly Cited
2004
Highly Cited
2004
Aberrant activation of Ras signaling is a common finding in human glioblastomas. To determine the contribution of Ras gene… (More)
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