Skip to search formSkip to main contentSkip to account menu

oxoguanine glycosylase 1, human

Known as: OGG1, DNA-(Apurinic or Apyrimidinic Site) Lyase, DNA-Apurinic or Apyrimidinic Site Lyase 
N-glycosylase/DNA lyase (345 aa, ~39 kDa) is encoded by the human OGG1 gene. This protein is involved in nucleotide excision repair.
National Institutes of Health

Related topics

Related topics

12 relations
Base Excision RepairCell NucleusClass II AP EndonucleaseConventional (Clear Cell) Renal Cell Carcinoma

Broader (1)

DNA glycosylase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Oxidative DNA damage repair in mammalian cells: a new perspective.
Highly Cited
2006
Highly Cited
2006
The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain
Highly Cited
2006
Highly Cited
2006
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner
Highly Cited
2006
Highly Cited
2006
Redox Regulation of Human OGG1 Activity in Response to Cellular Oxidative Stress
ABSTRACT 8-Oxoguanine (8-oxoG), a common and mutagenic form of oxidized guanine in DNA, is eliminated mainly through base… 
Highly Cited
2004
Highly Cited
2004
Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg1 DNA Glycosylases
The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine. In Myh−/− mice, there was no time-dependent… 
Highly Cited
2002
Highly Cited
2002
The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk.
The human OGG1 (hOGG1) gene encodes a DNA glycosylase that is involved in the excision repair of 8-hydroxy-2'-deoxyguanine (8-OH… 
Highly Cited
2001
Highly Cited
2001
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.
Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative… 
Highly Cited
1999
Highly Cited
1999
Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.
We identified seven alternatively spliced forms of human 8-oxoguanine DNA glycosylase (OGG1) mRNAs, classified into two types… 
Highly Cited
1999
Highly Cited
1999
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
The human homologue of the yeast OGG1 gene, hOGG1, has been cloned, and its genetic structure has been determined. Several… 
Highly Cited
1998
Highly Cited
1998
Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours
The human OGG1 gene encodes a DNA glycosylase activity catalysing the excision of the mutagenic lesion 7,8-dihydro-8-oxoguanine… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)