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oxoguanine glycosylase 1, human

Known as: OGG1, DNA-(Apurinic or Apyrimidinic Site) Lyase, DNA-Apurinic or Apyrimidinic Site Lyase 
N-glycosylase/DNA lyase (345 aa, ~39 kDa) is encoded by the human OGG1 gene. This protein is involved in nucleotide excision repair.
National Institutes of Health

Related topics

Related topics

12 relations
Base Excision RepairCell NucleusClass II AP EndonucleaseConventional (Clear Cell) Renal Cell Carcinoma

Broader (1)

DNA glycosylase

Papers overview

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2010
2010
Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells.
2008
2008
Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism
It is possible that oxidatively damaged DNA which arises as a result of radiotherapy may be involved in the therapeutic effect of… 
2007
2007
Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas.
Highly Cited
2005
Highly Cited
2005
Cadmium Down-regulates Human OGG1 through Suppression of Sp1 Activity*
Cadmium is a well known human and animal carcinogen and is a ubiquitous contaminant in the environment. Although the carcinogenic… 
2003
2003
Evaluation of a microarray for genotyping polymorphisms related to xenobiotic metabolism and DNA repair.
We present an oligonucleotide microarray ("MetaboChip") based on the arrayed primer extension (APEX) technique, allowing… 
Highly Cited
2001
Highly Cited
2001
Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein.
Clustered damages are formed in DNA by ionising radiation and radiomimetic anticancer agents and are thought to be biologically… 
Review
2001
Review
2001
DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes.
2000
2000
Detection of 8-oxoG DNA glycosylase activity and OGG1 transcripts in the rat CNS.
Highly Cited
1999
Highly Cited
1999
Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation.
1999
1999
Structure and chromosome location of human OGG1
OGG1 (alias MMH) encodes an 8-hydroxyguanine glycosylase, functionally homologous to bacterial mutM. Here, we report its genomic… 
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