oxoguanine glycosylase 1, human

Known as: OGG1, DNA-(Apurinic or Apyrimidinic Site) Lyase, DNA-Apurinic or Apyrimidinic Site Lyase 
N-glycosylase/DNA lyase (345 aa, ~39 kDa) is encoded by the human OGG1 gene. This protein is involved in nucleotide excision repair.
National Institutes of Health

Related topics

Related topics

12 relations
Base Excision RepairCell NucleusClass II AP EndonucleaseConventional (Clear Cell) Renal Cell Carcinoma
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Broader (1)

DNA glycosylase

Papers overview

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2014
2014
Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway.
8-Oxoguanine-DNA glycosylase-1 (OGG1) is the primary enzyme for repairing 7,8-dihydro-8-oxoguanine (8-oxoG) via the DNA base… (More)
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2012
2012
8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction
Oxidative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8… (More)
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2011
2011
Poly ( ADP-ribose ) Polymerase 1 ( PARP-1 ) Binds to 8-oxoguanine-DNA Glycosylase ( OGG 1 )
Background: Oxidative stress-induced DNA damage is repaired by proteins in the base excision pathway. Results: We identified a… (More)
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2007
2007
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease.
Human 8-oxoguanine-DNA glycosylase (OGG1) is the main human base excision protein that removes a mutagenic lesion 8-oxoguanine (8… (More)
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2005
2005
Phosphorylation of human oxoguanine DNA glycosylase (α-OGG1) modulates its function
Oxoguanine DNA glycosylase (OGG1) initiates the repair of 8-oxoguanine (8-oxoG), a major oxidative DNA base modification that has… (More)
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Highly Cited
2003
Highly Cited
2003
Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.
Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… (More)
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Highly Cited
2001
Highly Cited
2001
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.
8-Oxoguanine-DNA glycosylase 1 (OGG1), with intrinsic AP lyase activity, is the major enzyme for repairing 7,8-dihydro-8… (More)
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Highly Cited
2001
Highly Cited
2001
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.
Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative… (More)
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Highly Cited
2001
Highly Cited
2001
DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.
8-oxoguanine DNA glycosylase 1 (OGG1) is a DNA repair enzyme that excises 7,8-dihydro-8-oxoguanine (8oxoG) from DNA. Since 8oxoG… (More)
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Highly Cited
1999
Highly Cited
1999
Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.
We identified seven alternatively spliced forms of human 8-oxoguanine DNA glycosylase (OGG1) mRNAs, classified into two types… (More)
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