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Protective roles of bacterioruberin and intracellular KCl in the resistance of Halobacterium salinarium against DNA-damaging agents.
TLDR
Results suggest that bacterioruberin and intracellular KCl of H. salinarium protect this organism against the lethal effects of oxidative DNA-damaging agents.
TopBP1 associates with NBS1 and is involved in homologous recombination repair.
Human DNA glycosylases involved in the repair of oxidatively damaged DNA.
  • H. Ide, M. Kotera
  • Biology, Chemistry
    Biological & pharmaceutical bulletin
  • 1 April 2004
TLDR
The depletion of functional DNA glycosylases using covalent trapping may reduce the BER capacity of cancer cells, hence potentiating the efficacy of anticancer drugs or radiation therapy.
Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells*
TLDR
It is shown that the upper size limit of CLPs amenable to mammalian NER is relatively small so that NER cannot participate in the repair of chromosomal DPCs in mammalian cells, and the versatile and conserved role of HR in tolerance of D PCs among species is demonstrated.
A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion.
TLDR
The sensitivity and simplicity of the ARP assay should provide a potentially powerful method for the quantitation of AP sites or other DNA lesions containing an aldehyde group.
Differential Specificity of Human and Escherichia coli Endonuclease III and VIII Homologues for Oxidative Base Lesions*
TLDR
Detailed analysis of the cellular activity suggests that hNEIL1 has a significant role in the repair of 5S-Tg in human cells.
Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
TLDR
Data indicate a dual role of hSMUG1 as a backup enzyme for UNG and a primary repair enzyme for a subset of oxidized pyrimidines such as fU, hmU, and hoU.
Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams.
TLDR
The results suggest that the adverse biological effect of the ionizing radiation is not simply accounted for by the yield of clustered DNA damage, and that the complexity of the clustered damage needs to be considered to understand the biological consequences of ionizing Radiation.
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols
TLDR
In extracts from mutant mouse liver, it is found that instead of mNTH1 activity, at least two novel DNA glycosylase activities against Tg are found, one activity is significantly higher in the mutant than in wild‐type mouse in mitochondria, while the other is another nuclear glyCosylase for Tg.
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.
TLDR
It is reported that Ape1, the major apurinic/apyrimidinic endonuclease in human cells, is the damage- specific endonUClease involved in NIR, and the kinetic constants indicate that APe1-catalysed NIR activity is highly efficient.
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