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omuralide

National Institutes of Health

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Lactones

Papers overview

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2014
2014
Development of Small Molecular Proteasome Inhibitors Using a Caenorhabditis elegans Screen
We have developed a screening protocol to identify compounds with characteristics of small molecule proteasome inhibitors using… 
2014
2014
Stereoselective Synthesis of an Omuralide Analogue Through a Lewis Acid Catalyzed Reaction of an Aldehyde and an Oxazole
p. 3 Biological Introduction p. 3-10 Experimental Goals and Purpose p. 10-15 Results and Discussion p. 15-26 
2009
2009
Synthesis of Proteasome Inhibitor Omuralide Featuring Stereocontrolled Ugi Reaction and Novel Convertible Isocyanide
Stereocontrolled formal total synthesis of proteasome inhibitor omuralide is described. This is featured by the application of… 
2008
2008
New convertible isocyanides for the Ugi Reaction : application to the stereoselective synthesis of omuralide
Omuralide, derived from natural product lactacystin, is a member of a family of proteasome inhibitors, including the… 
2007
2007
Partial reduction of pyrroles: application to natural product synthesis.
The partial reduction of N-Boc pyrroles has been explored giving stereoselective routes to disubstituted pyrrolines in good… 
2006
2006
Prediction of the mechanism of action of omuralide (clasto-lactacystin beta-lactone) on human cathepsin A based on a structural model of the yeast proteasome beta5/PRE2-subunit/omuralide complex.
2004
2004
Microbial serine carboxypeptidase inhibitors--comparative analysis of actions on homologous enzymes derived from man, yeast and wheat.
The actions of peptidase inhibitors derived from Streptomycete on human cathepsin A (hCath A), yeast carboxypeptidase Y (CPY… 
1999
1999
Recent progress of the research on novel microbial metabolites
Abstract 
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