omuralide
National Institutes of Health
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We have developed a screening protocol to identify compounds with characteristics of small molecule proteasome inhibitors using…
p. 3 Biological Introduction p. 3-10 Experimental Goals and Purpose p. 10-15 Results and Discussion p. 15-26
Stereocontrolled formal total synthesis of proteasome inhibitor omuralide is described. This is featured by the application of…
Omuralide, derived from natural product lactacystin, is a member of a family of proteasome inhibitors, including the…
The partial reduction of N-Boc pyrroles has been explored giving stereoselective routes to disubstituted pyrrolines in good…
[reaction: see text] Syntheses of two novel omuralide derivatives are described.
The actions of peptidase inhibitors derived from Streptomycete on human cathepsin A (hCath A), yeast carboxypeptidase Y (CPY…