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oltipraz

Known as: 4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thione, 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-, 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione 
A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as… 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (1)

35 972 R.P.

Broader (6)

Anticarcinogenic AgentsAntiviral AgentsPyrazinesReverse Transcriptase Inhibitors
NCIt Antineoplastic Agent Terminologyoltipraz/vitamin A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inhibition of Arachidonic Acid and Iron-Induced Mitochondrial Dysfunction and Apoptosis by Oltipraz and Novel 1,2-Dithiole-3-thione Congeners
4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz), a prototype drug candidate containing a 1,2-dithiole-3-thione moiety… 
Highly Cited
2003
Highly Cited
2003
Is antimicrobial susceptibility testing necessary before second‐line treatment for Helicobacter pylori infection?
Background:  An antimicrobial susceptibility test for Helicobacter pylori before second‐line treatment is often performed… 
Highly Cited
2002
Highly Cited
2002
Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation.
Liver cirrhosis (LC) is a chronic disease with high mortality rate. In the United States and Western world as well as Asian… 
Highly Cited
2002
Highly Cited
2002
Transcriptional Induction of CYP1A1 by Oltipraz in Human Caco-2 Cells Is Aryl Hydrocarbon Receptor- and Calcium-dependent*
Oltipraz, a synthetic derivative of the cruciferous vegetable product 1,2-dithiole-3-thione, is considered as one of the most… 
Highly Cited
1998
Highly Cited
1998
Identification of dithiolethiones with better chemopreventive properties than oltipraz.
Oltipraz and related dithiolethiones are an important class of chemopreventive agents. Studies were undertaken to identify cancer… 
Highly Cited
1998
Highly Cited
1998
Photodynamic therapy of naturally occurring tumors in animals using a novel benzophenothiazine photosensitizer.
5-Ethylamino-9-diethylaminobenzo[a]phenothiazinium chloride (EtNBS) is a novel photodynamic therapy (PDT) photosensitizer with… 
Highly Cited
1997
Highly Cited
1997
Opsonized zymosan stimulates the redistribution of protein kinase C isoforms in human neutrophils.
We examined the ability of opsonized zymosan (OPZ) to stimulate translocation of protein kinase C (PKC) isoforms in human… 
Highly Cited
1996
Highly Cited
1996
Alcohol modulates alveolar macrophage tumor necrosis factor-alpha, superoxide anion, and nitric oxide secretion in the rat.
We investigated the effect of alcohol (ethanol) on the ability of the alveolar macrophage to produce tumor necrosis factor-alpha… 
Highly Cited
1996
Highly Cited
1996
Phagocytic activation induces formation of platelet-activating factor in human monocyte-derived macrophages and in macrophage-derived foam cells. Relevance to the inflammatory reaction in…
Monocyte-derived macrophages and macrophage-derived foam cells in arterial tissue may undergo phagocytic activation and thereby… 
Highly Cited
1992
Highly Cited
1992
Regulation of microglial function by interferons
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