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olesoxime

Known as: cholest-4-en-3-one, oxime 
National Institutes of Health

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TRO19622

Papers overview

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2019
2019
Cytoprotective effects of olesoxime on isolated human pancreatic islets in order to attenuate apoptotic pathway.
2018
2018
A Long-Term, Open-Label Follow-Up Study of Olesoxime in Patients with Type 2 or Non-Ambulatory Type 3 Spinal Muscular Atrophy who Participated in a Placebo-Controlled Phase 2 Trial (S46.002)
Objective: OLEOS (NCT02628743) is an open-label extension study assessing the long-term safety and efficacy of olesoxime in… 
2017
2017
Neuroprotection As a Therapeutic Approach for Spinal Muscular Atrophy
2016
2016
The calpain-suppressing effects of olesoxime in Huntington's disease
ABSTRACT Olesoxime, a small molecule drug candidate, has recently attracted attention due to its significant beneficial effects… 
2016
2016
L20 Olesoxime targets calpain overactivation in models of huntington’s disease
Background A long-term treatment study of BACHD rats with olesoxime, a mitochondria-targeting drug, revealed beneficial effects… 
2014
2014
Trophos will present results of pivotal phase II/III study of olesoxime in spinal muscular atrophy patients at the American Academy of Neurology (AAN)
  • 2014
  • Corpus ID: 52266155
Marseille and Evry, France, April 28, 2014 Trophos and AFM-Telethon (The French Muscular Dystrophy Association) today announce… 
2014
2014
Results of a Phase II Study to Assess Safety and Efficacy of Olesoxime (TRO19622) in 3- to 25-Year-Old Spinal Muscular Atrophy Patients
2014
2014
G.O.19 Results of a phase II study to assess safety and efficacy of olesoxime (TRO19622) in 3–25 years old spinal muscular atrophy patients
2014
2014
Mitochondrial Membrane Fluidity is Consistently Increased in Different Models of Huntington Disease: Restorative Effects of Olesoxime
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the huntingtin gene… 
2013
2013
Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF
Olesoxime is a small cholesterol–oxime promoting rat embryonic motor neurons survival in the absence of trophic factors. Because… 
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