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olesoxime

Known as: cholest-4-en-3-one, oxime 
National Institutes of Health

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TRO19622

Papers overview

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Review
2020
Review
2020
Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs
There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial… 
2017
2017
Olesoxime Inhibits Cardioplegia-Induced Ischemia/Reperfusion Injury. A Study in Langendorff-Perfused Rabbit Hearts
Objective: During cardioplegia, which is often used in cardiac surgery, the heart is subjected to global ischemia/reperfusion… 
2016
2016
The calpain-suppressing effects of olesoxime in Huntington's disease
ABSTRACT Olesoxime, a small molecule drug candidate, has recently attracted attention due to its significant beneficial effects… 
2016
2016
Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction.
Highly Cited
2015
Highly Cited
2015
Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial
Patients with ALS may have insufficientenergy substrates, due to dysphagia and hypermetabolism, which adversely affects the… 
2015
2015
Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
Huntington's disease is a fatal human neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene, which… 
2013
2013
Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF
Olesoxime is a small cholesterol–oxime promoting rat embryonic motor neurons survival in the absence of trophic factors. Because… 
2011
2011
Targeting Mitochondria by Olesoxime or Complement 1q Binding Protein as a Novel Management for Autism: A Hypothesis
Excitotoxicity, oxidative stress, and mitochondrial dysfunction are associated with autism. Considering the preventive role of… 
Review
2010
Review
2010
Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.
  • L. Martin
  • IDrugs : the investigational drugs journal
  • 2010
  • Corpus ID: 6884827
Effective therapies are needed for amyotrophic lateral sclerosis (ALS), a debilitating and fatal motor neuron disease. Cell and… 
2010
2010
Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells.
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