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olesoxime

Known as: cholest-4-en-3-one, oxime 
National Institutes of Health

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TRO19622

Papers overview

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2019
2019
Cytoprotective effects of olesoxime on isolated human pancreatic islets in order to attenuate apoptotic pathway.
2018
2018
A Long-Term, Open-Label Follow-Up Study of Olesoxime in Patients with Type 2 or Non-Ambulatory Type 3 Spinal Muscular Atrophy who Participated in a Placebo-Controlled Phase 2 Trial (S46.002)
Objective: OLEOS (NCT02628743) is an open-label extension study assessing the long-term safety and efficacy of olesoxime in… 
2017
2017
Neuroprotection As a Therapeutic Approach for Spinal Muscular Atrophy
2016
2016
The calpain-suppressing effects of olesoxime in Huntington's disease
ABSTRACT Olesoxime, a small molecule drug candidate, has recently attracted attention due to its significant beneficial effects… 
2016
2016
L20 Olesoxime targets calpain overactivation in models of huntington’s disease
Background A long-term treatment study of BACHD rats with olesoxime, a mitochondria-targeting drug, revealed beneficial effects… 
2014
2014
Trophos will present results of pivotal phase II/III study of olesoxime in spinal muscular atrophy patients at the American Academy of Neurology (AAN)
  • 2014
  • Corpus ID: 52266155
Marseille and Evry, France, April 28, 2014 Trophos and AFM-Telethon (The French Muscular Dystrophy Association) today announce… 
2014
2014
Results of a Phase II Study to Assess Safety and Efficacy of Olesoxime (TRO19622) in 3- to 25-Year-Old Spinal Muscular Atrophy Patients
2014
2014
G.O.19 Results of a phase II study to assess safety and efficacy of olesoxime (TRO19622) in 3–25 years old spinal muscular atrophy patients
2013
2013
Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF
Olesoxime is a small cholesterol–oxime promoting rat embryonic motor neurons survival in the absence of trophic factors. Because… 
2012
2012
Drug pipeline: 1Q12
383 fibrosis. The curse of neurodegenerative disorders again claimed two experimental drugs: Medivation’s Dimebon and Trophos… 
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