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olesoxime

Known as: cholest-4-en-3-one, oxime 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
BACKGROUND Spinal muscular atrophy (SMA) is a progressive motor neuron disease causing loss of motor function and reduced life… Expand
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2015
2015
Patients with ALS may have insufficientenergy substrates, due to dysphagia and hypermetabolism, which adversely affects the… Expand
Highly Cited
2014
Highly Cited
2014
To assess the efficacy and safety of olesoxime, a molecule with neuroprotective properties, in patients with amyotrophic lateral… Expand
Highly Cited
2013
Highly Cited
2013
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death… Expand
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Highly Cited
2012
Highly Cited
2012
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. The pathology is mimicked to a striking degree in… Expand
Highly Cited
2012
Highly Cited
2012
Multiple sclerosis is a neurodegenerative disease characterized by episodes of immune attack of oligodendrocytes leading to… Expand
Highly Cited
2012
Highly Cited
2012
Anti-neoplastic agents in the platinum-complex, taxane, vinca alkaloid, and proteasome-inhibitor classes induce a dose-limiting… Expand
Review
2010
Review
2010
Olesoxime (TRO19622) is a novel mitochondrial-targeted neuroprotective compound undergoing a pivotal clinical efficacy study in… Expand
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Review
2010
Review
2010
  • Lee J Martin
  • IDrugs : the investigational drugs journal
  • 2010
  • Corpus ID: 6884827
Effective therapies are needed for amyotrophic lateral sclerosis (ALS), a debilitating and fatal motor neuron disease. Cell and… Expand
Highly Cited
2009
Highly Cited
2009
ABSTRACT Olesoxime is a small cholesterol‐like molecule that was discovered in a screening program aimed at finding treatment for… Expand