All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody
Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture
Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a…
- C. Serradeil-Le Gal, J. Wagnon, G. Le Fur
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 March 2002
SSR149415 is a potent, selective, and orally active V1b receptor antagonist and deserves to be clinically investigated in the field of stress and anxiety.
Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease
It is concluded that the cholesterol biosynthetic pathway is impaired in HD cells, mice, and human subjects, and that the search for HD therapies should also consider cholesterol levels as both a potential target and disease biomarker.
Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture
- R. Mirsky, J. Winter, E. Abney, R. Pruss, J. Gavrilovic, M. Raff
- BiologyJournal of Cell Biology
- 1 March 1980
It is suggested that only Schwann cells which have been induced to myelinate make detectable amounts of galactocerebroside, sulfatide, myelin basic protein (BP), or the major peripheral myelin glycoprotein (P0).
Agonist-activated cobalt uptake identifies divalent cation—Permeable kainate receptors on neurons and glial cells
Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
In vivo and in vitro, TRO19622 rescued motor neurons from axotomy-induced cell death in neonatal rats and promoted nerve regeneration following sciatic nerve crush in mice, suggesting a potential mechanism for its neuroprotective activity.
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.
Of the eight clonal EGF nonresponder variants selected by this procedure, none retains a functional EGF receptor and the EGFnonresponsive va-riant lines still retain the ability to respond to other mitogens.
Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy
Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results.
This study in STEMI patients treated with contemporary mechanical revascularization principles did not show any effect of TRO40303 in limiting reperfusion injury of the ischaemic myocardium.