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All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody
It is suggested that all vertebrate and invertebrate intermediate filament proteins share a common antigenic determinant and the possibility that all intermediate filaments contain a 66,000 molecular weight protein. Expand
Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture
Although Ran-1 is expressed on glial and neuronal tumours, it was not found on normal astrocytes, oligodendrocyte or neurons and the 'large external transformation sensitive' (LETS) protein could be detected on fibroblasts and leptomeningeal cells but not on neurons or glial cells. Expand
Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a
SSR149415 is a potent, selective, and orally active V1b receptor antagonist and deserves to be clinically investigated in the field of stress and anxiety. Expand
Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture
It is suggested that only Schwann cells which have been induced to myelinate make detectable amounts of galactocerebroside, sulfatide, myelin basic protein (BP), or the major peripheral myelin glycoprotein (P0). Expand
Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease
It is concluded that the cholesterol biosynthetic pathway is impaired in HD cells, mice, and human subjects, and that the search for HD therapies should also consider cholesterol levels as both a potential target and disease biomarker. Expand
Agonist-activated cobalt uptake identifies divalent cation—Permeable kainate receptors on neurons and glial cells
The agonist-dependent activation of divalent cation influx through different kainate receptors could be correlated with expression of certain kainATE receptor subunit combinations and are indicative of kainates receptors that may contribute to excitatory amino acid-mediated neurotoxicity. Expand
Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
In vivo and in vitro, TRO19622 rescued motor neurons from axotomy-induced cell death in neonatal rats and promoted nerve regeneration following sciatic nerve crush in mice, suggesting a potential mechanism for its neuroprotective activity. Expand
Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results.
This study in STEMI patients treated with contemporary mechanical revascularization principles did not show any effect of TRO40303 in limiting reperfusion injury of the ischaemic myocardium. Expand
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.
  • R. Pruss, H. Herschman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 September 1977
Of the eight clonal EGF nonresponder variants selected by this procedure, none retains a functional EGF receptor and the EGFnonresponsive va-riant lines still retain the ability to respond to other mitogens. Expand
Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy
NewSMN2;Smn(-/-) lines carrying one to four copies of the human SMN2 gene, carrying an intermediate phenotype with delayed appearance of motor defects and developmental breathing disorders reminiscent of those found in severe SMA patients are reported. Expand