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Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex
Statins have been reported to lower the risk of developing Alzheimer's disease; however, the mechanism of this potentially important neuroprotective action is not understood. Lowering cholesterolExpand
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Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.
AIMS Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering AβExpand
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Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
Post-translational modification of small GTPases by farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential contribution to cancer, cardiovascularExpand
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Statin effects on cholesterol micro-domains in brain plasma membranes.
Recent epidemiological studies revealed inhibitors of the hydroxymethylglutaryl-coenzyme A reductase, so-called statins, to be effective in lowering the prevalence of Alzheimer's disease (AD). InExpand
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Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo.
UNLABELLED Elevated oxidative and nitrosative stress both impair the integrity and functioning of brain tissue, especially in aging. As long-term intake of plant foods rich in antioxidant phenolics,Expand
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Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Phosphorylation of the inhibitory protein IkappaBalpha by the activated IkappaB kinase (IKK) is a crucial step in the activation of the transcription factor NF-kappaB. In neurons of the mammalianExpand
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Cholesterol Modulates the Membrane- Disordering Effects of Beta-Amyloid Peptides in the Hippocampus: Specific Changes in Alzheimer’s Disease
Cholesterol represents an important determinant of the physical state of biological membranes. In Alzheimer’s disease (AD) brains, specific changes in the distribution of cholesterol and itsExpand
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Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease.
Amyloid beta-protein (Abeta) is thought to be one of the primary factors causing neurodegeneration in Alzheimer's disease (AD). This protein is an amphipathic molecule that perturbs membranes, bindsExpand
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Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bcl-2 inhibitor HA 14-1 orExpand
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The interaction of beta-amyloid protein with cellular membranes stimulates its own production.
Gradual changes in steady-state levels of beta amyloid peptides (Abeta) in brain are considered an initial step in the amyloid cascade hypothesis of Alzheimer's disease. Abeta is a product of theExpand
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