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Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex
- L. Johnson-Anuna, G. Eckert, W. G. Wood
- BiologyJournal of Pharmacology and Experimental…
- 1 February 2005
To understand the molecular targets of statins in brain, DNA microarrays were used to identify gene expression patterns in the cerebral cortex of mice chronically treated with lovASTatin, pravastatin, and simvastatin and revealed 15 genes involved in cell growth and signaling and trafficking that were similarly changed by all three statins.
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.
It is shown for the first time that mitochondrion-derived ROS are sufficient to trigger Aβ production in vitro and in vivo and that Aβ itself leads to mitochondrial dysfunction and increased ROS levels.
Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo.
- S. Schaffer, Maciej Podstawa, F. Visioli, P. Bogani, W. Müller, G. Eckert
- BiologyJournal of agricultural and food chemistry
- 27 May 2007
Ex vivo data provide the first evidence of neuroprotective effects of oral hydroxytyrosol intake, as shown by reduced basal and stress-induced lipid peroxidation and an effect suggestive of cytoprotection.
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
Statin effects on cholesterol micro-domains in brain plasma membranes.
Mitochondrial Dysfunction—A Pharmacological Target in Alzheimer's Disease
Since mitochondrial dysfunction represents an early event in disease progression, one reason for the disappointing clinical results could be that pharmacological interventions might came too late, so more studies are needed that focus on therapeutic strategies starting before severe disease progress.
Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects
Findings in AD animal and cell models indicate that mitochondrial protection and subsequent reduction of oxidative stress are important targets for prevention and long-term treatment of early stages of AD.
Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease.
Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment
Metabolism of Boswellic Acids in Vitro and in Vivo
This study indicates that the efficacy of B. serrata extract may be enhanced by increasing the bioavailability of AKBA, the main active ingredients of boswellic acids, which is not deacetylated to KBA.