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octimibate

Known as: 8-((1,4,5-triphenylimidazol-2-yl)oxy)octanoic acid 
An acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with antilipidemic, antiatherosclerotic, and antithrombotic activity. In an animal… 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

BMY 22389

Broader (1)

Imidazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Factors affecting prostacyclin receptor agonist efficacy in different cell types.
2001
2001
Prostacyclin receptor‐independent inhibition of phospholipase C activity by non‐prostanoid prostacyclin mimetics
Chinese hamster ovary (CHO) cells were transiently transfected with the mouse prostacyclin (mIP) receptor to examine IP agonist… 
1996
1996
The inhibitory effects of non-prostanoid prostacyclin mimetics on rat neutrophil function.
1995
1995
Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors.
1993
1993
Prostacyclin agonists reduce early atherosclerosis in hyperlipidemic hamsters. Octimibate and BMY 42393 suppress monocyte chemotaxis, macrophage cholesteryl ester accumulation, scavenger receptor…
We determined the effects of two prostacyclin agonists (octimibate and BMY 42393) on the progression of the fatty streak in vivo… 
1991
1991
Primate vascular responses to octimibate, a non‐prostanoid agonist at the prostacyclin receptor
1 Octimibate is a potent inhibitor of human platelet aggregation, and appears to act (at least in part) through the prostacyclin… 
1990
1990
Influence of the acyl-coenzyme A:cholesterol--acyltransferase inhibitor octimibate on cholesterol transport in rat mesenteric lymph.
The effect of the new inhibitor of acyl-coenzyme A:cholesterol-acyltransferase, octimibate (sodium 8-[1,4,5-triphenyl-1H… 
1990
1990
Regulation of phospholipid biosynthesis during cholesterol influx and high density lipoprotein-mediated cholesterol efflux in macrophages.
We have studied the rate of phospholipid synthesis and turnover in mouse peritoneal macrophages in reaction to cholesterol influx… 
Highly Cited
1988
Highly Cited
1988
Ca++ Antagonists and ACAT Inhibitors Promote Cholesterol Efflux from Macrophages by Different Mechanisms: II. Characterization of Intracellular Morphologic Changes
The effects of the slow Ca++ channel blocker, nlfedlplne, and ACAT inhibitor, octlmlbate, on cholesterol-loaded macrophages were… 
1988
1988
Antiatherosclerotic and antihyperlipidemic effects of octimibate sodium in rabbits.
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