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nucleophosmin

Known as: B23 Nuclear Matrix Protein, NPM1, nucleophosmid 
Nucleophosmin (294 aa, ~33 kDa) is encoded by the human NPM1 gene. This protein is involved in ribosomal function.
National Institutes of Health

Related topics

Related topics

10 relations
Cell NucleolusLiver carcinomaNPM1 geneNPM1 wt Allele

Narrower (2)

NPM1 protein, humanNpm1 protein, mouse

Papers overview

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Highly Cited
2012
Highly Cited
2012
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The… 
Highly Cited
2009
Highly Cited
2009
Recurring mutations found by sequencing an acute myeloid leukemia genome.
BACKGROUND The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not… 
Review
2007
Review
2007
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.
The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling protein that is localized mainly in the… 
Review
2006
Review
2006
Nucleophosmin and cancer
NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed… 
Highly Cited
2005
Highly Cited
2005
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
BACKGROUND Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF… 
Highly Cited
2005
Highly Cited
2005
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.
Nucleophosmin (NPM1) exon-12 gene mutations are the hallmark of a large acute myelogenous leukemia (AML) subgroup with normal… 
Highly Cited
2005
Highly Cited
2005
Role of nucleophosmin in embryonic development and tumorigenesis
Nucleophosmin (also known as NPM, B23, NO38) is a nucleolar protein directly implicated in cancer pathogenesis, as the NPM1 gene… 
Highly Cited
2005
Highly Cited
2005
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations.
To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic shuttle protein in younger adults… 
Highly Cited
2005
Highly Cited
2005
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic…
Mutations in nucleophosmin NPM1 are the most frequent acquired molecular abnormalities in acute myeloid leukemia (AML). We… 
Highly Cited
2002
Highly Cited
2002
Nucleophosmin regulates the stability and transcriptional activity of p53
Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and… 
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