nucleophosmin

Known as: B23 Nuclear Matrix Protein, NPM1, nucleophosmid 
Nucleophosmin (294 aa, ~33 kDa) is encoded by the human NPM1 gene. This protein is involved in ribosomal function.
National Institutes of Health

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Cell NucleolusLiver carcinomaNPM1 geneNPM1 wt Allele
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Papers overview

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Review
2006
Review
2006
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.
The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling protein that is localized mainly in the… (More)
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Highly Cited
2006
Highly Cited
2006
Nucleophosmin is essential for ribosomal protein L5 nuclear export.
Nucleophosmin (NPM/B23) is a key regulator in the regulation of a number of processes including centrosome duplication… (More)
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Highly Cited
2005
Highly Cited
2005
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
BACKGROUND Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF… (More)
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Highly Cited
2005
Highly Cited
2005
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations.
To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic shuttle protein in younger adults… (More)
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Highly Cited
2005
Highly Cited
2005
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.
Nucleophosmin (NPM1) exon-12 gene mutations are the hallmark of a large acute myelogenous leukemia (AML) subgroup with normal… (More)
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Highly Cited
2005
Highly Cited
2005
Role of nucleophosmin in embryonic development and tumorigenesis
Nucleophosmin (also known as NPM, B23, NO38) is a nucleolar protein directly implicated in cancer pathogenesis, as the NPM1 gene… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic…
Mutations in nucleophosmin NPM1 are the most frequent acquired molecular abnormalities in acute myeloid leukemia (AML). We… (More)
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Highly Cited
2005
Highly Cited
2005
Nucleophosmin is required for DNA integrity and p19Arf protein stability.
Nucleophosmin (NPM) is a nucleolar phosphoprotein that binds the tumor suppressors p53 and p19(Arf) and is thought to be… (More)
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Highly Cited
2002
Highly Cited
2002
Nucleophosmin regulates the stability and transcriptional activity of p53
Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and… (More)
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Highly Cited
2000
Highly Cited
2000
Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication
In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E triggers initiation of both events… (More)
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