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nucleophosmin

Known as: B23 Nuclear Matrix Protein, NPM1, nucleophosmid 
Nucleophosmin (294 aa, ~33 kDa) is encoded by the human NPM1 gene. This protein is involved in ribosomal function.
National Institutes of Health

Related topics

Related topics

10 relations
Cell NucleolusLiver carcinomaNPM1 geneNPM1 wt Allele

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NPM1 protein, humanNpm1 protein, mouse

Papers overview

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Highly Cited
2010
Highly Cited
2010
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3…
PURPOSE To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2… 
Highly Cited
2010
Highly Cited
2010
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
PURPOSE To analyze the frequency and associations with prognostic markers and outcome of mutations in IDH genes encoding… 
Review
2007
Review
2007
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.
The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling protein that is localized mainly in the… 
Highly Cited
2005
Highly Cited
2005
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic…
Mutations in nucleophosmin NPM1 are the most frequent acquired molecular abnormalities in acute myeloid leukemia (AML). We… 
Highly Cited
2005
Highly Cited
2005
Temporal and spatial control of nucleophosmin by the Ran–Crm1 complex in centrosome duplication
Centrosome duplication is tightly controlled during faithful cell division, and unnecessary reduplication can lead to… 
Highly Cited
2002
Highly Cited
2002
Nucleophosmin regulates the stability and transcriptional activity of p53
Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and… 
Highly Cited
2000
Highly Cited
2000
Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway.
More than half of anaplastic large-cell lymphomas (ALCLs) have a chromosomal translocation t(2;5) that leads to the expression of… 
Highly Cited
1999
Highly Cited
1999
Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
I N THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute promyelocytic leukemia (APL) emerged as a… 
Highly Cited
1997
Highly Cited
1997
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis
The NPM-ALK fusion gene, formed by the t(2;5)(p23;q35) translocation in non-Hodgkin's lymphoma, encodes a 75-kDa hybrid protein… 
Highly Cited
1994
Highly Cited
1994
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T… 
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