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nucleic acid biosynthesis

National Institutes of Health

Papers overview

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2018
2018
Polymerases (Pols) synthesize the double-stranded nucleic acids in the Watson-Crick (W-C) conformation, which is critical for DNA… Expand
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Review
2014
Review
2014
Worldwide, tuberculosis (TB) is the leading cause of death among curable infectious diseases. The emergence of multidrug… Expand
2004
2004
Type IB topoisomerases are enzymes essential for the orderly synthesis of nucleic acids and are the molecular target for… Expand
2004
2004
ABSTRACT Distamycin A has been described as an inhibitor of the cellular pathogenesis of vaccinia virus in culture. Distamycin is… Expand
Highly Cited
2000
Highly Cited
2000
Cantharidin is isolated from Mylabris phalerata Pallas and is a potent inhibitor of hepatocellular carcinoma cells (Hep 3B cells… Expand
1983
1983
Cyanocycline A was cytotoxic against Meth A cells in vitro, and also showed marked activity against the same cell line grown as… Expand
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1976
1976
The degree of inhibition of mammalian DNA-dependent RNA polymerases I and II and Moloney leukemia virus RNA-dependent DNA… Expand
Review
1963
Review
1963
Summary A review is presented of the clinical applications of 5-fluorouracil (5-FU) and 5-fluoro-2′-deoxyuridine (5-FUDR). This… Expand
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Highly Cited
1959
Highly Cited
1959
We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by… Expand
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Highly Cited
1958
Highly Cited
1958
Summary 1.A study of the effects of fluorinated pyrimidines on nucleic acid biosynthesis has been carried out in suspensions of… Expand