nucleic acid biosynthesis
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Polymerases (Pols) synthesize the double-stranded nucleic acids in the Watson-Crick (W-C) conformation, which is critical for DNA… Expand Worldwide, tuberculosis (TB) is the leading cause of death among curable infectious diseases. The emergence of multidrug… Expand Type IB topoisomerases are enzymes essential for the orderly synthesis of nucleic acids and are the molecular target for… Expand ABSTRACT Distamycin A has been described as an inhibitor of the cellular pathogenesis of vaccinia virus in culture. Distamycin is… Expand Cantharidin is isolated from Mylabris phalerata Pallas and is a potent inhibitor of hepatocellular carcinoma cells (Hep 3B cells… Expand Cyanocycline A was cytotoxic against Meth A cells in vitro, and also showed marked activity against the same cell line grown as… Expand The degree of inhibition of mammalian DNA-dependent RNA polymerases I and II and Moloney leukemia virus RNA-dependent DNA… Expand Summary A review is presented of the clinical applications of 5-fluorouracil (5-FU) and 5-fluoro-2′-deoxyuridine (5-FUDR). This… Expand We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by… Expand Summary 1.A study of the effects of fluorinated pyrimidines on nucleic acid biosynthesis has been carried out in suspensions of… Expand