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nitrile hydratase activity

Known as: NHase activity, 3-cyanopyridine hydratase activity, nitrile hydro-lyase activity 
Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. [EC:4.2.1.84]
National Institutes of Health

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nitrile hydratase

Papers overview

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Highly Cited
2017
Highly Cited
2017
Iridium-Catalyzed Reductive Strecker Reaction for Late-Stage Amide and Lactam Cyanation.
A new iridium-catalyzed reductive Strecker reaction for the direct and efficient formation of α-amino nitrile products from a… 
Highly Cited
2013
Highly Cited
2013
Lactic acid bacteria convert glucosinolates to nitriles efficiently yet differently from enterobacteriaceae.
Glucosinolates from the genus Brassica can be converted into bioactive compounds known to induce phase II enzymes, which may… 
Highly Cited
2012
Highly Cited
2012
A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper-free click reaction.
Highly Cited
2010
Highly Cited
2010
New synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of in situ generated nitrile imines and benzyne.
A new synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The… 
Highly Cited
2009
Highly Cited
2009
Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.
Highly Cited
2005
Highly Cited
2005
An entry to a chiral dihydropyrazole scaffold: enantioselective [3 + 2] cycloaddition of nitrile imines.
We have developed a versatile strategy to access dihydropyrazoles in highly enantioenriched form. Dipolar cycloaddition of… 
Highly Cited
2002
Highly Cited
2002
Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.
Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and… 
Highly Cited
2002
Highly Cited
2002
Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.
Several spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] were synthesized and evaluated for their… 
Highly Cited
2001
Highly Cited
2001
Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile.
Epidemiological and laboratory studies suggest that dietary broccoli may prevent or delay a variety of cancers. Broccoli and… 
Highly Cited
1986
Highly Cited
1986
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.
A series of peri-acylated gossylic nitriles were synthesized from gossypol dioxime by treatment of the dioxime with the… 
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