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Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine
On the basis of the material available both in the scientific literature and on the web, this paper aims to provide a pharmacological, chemical and behavioural overview of the novel compoundExpand
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5,6‐Methylenedioxy‐2‐aminoindane: from laboratory curiosity to ‘legal high’
The fully synthetic ‘legal high’ 5,6‐methylenedioxy‐2‐aminoindane (MDAI) is an analogue of 3,4‐methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010.Expand
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Skeletal diversity construction via a branching synthetic strategy.
A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA wasExpand
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Promoting innovation and excellence to face the rapid diffusion of Novel Psychoactive Substances in the EU: the outcomes of the ReDNet project
The recent emergence of new psychoactive compounds (novel psychoactive substances (NPS)) has raised prominent challenges in the fields of drug policy, substance use research, public health andExpand
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Assessment of structural diversity in combinatorial synthesis.
This article covers the combinatorial synthesis of small molecules with maximal structural diversity to generate a collection of pure compounds that are attractive for lead generation in aExpand
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Analysis of ‘legal high’ substances and common adulterants using handheld spectroscopic techniques
The identification of ‘legal highs’ is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniquesExpand
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Emergence and identification of new products of designer drug products from the internet
Original article can be found at : http://www.europeanpharmaceuticalreview.com/ Copyright Russell Publishing Ltd. [Due to publisher restrictions full text of this article is not available in the UHRA]
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Small molecule recognition of mephedrone using an anthracene molecular clip.
An anthracene molecular probe has been synthesised and shown to target mephedrone, a stimulant drug from the cathinone class of new psychoactive substances (NPS). A protocol has been developed toExpand
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Diversity oriented synthesis: a challenge for synthetic chemists.
TLDR
This article covers the diversity-oriented synthesis (DOS) of small molecules in order to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high-throughput screening approach useful for chemical genetics and drug discovery programmes. Expand
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