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The neural crest is a multipotent and migratory cell type that forms transiently in the developing vertebrate embryo. These cells… Expand Heterozygous mutations in the gene encoding the CHD (chromodomain helicase DNA-binding domain) member CHD7, an ATP-dependent… Expand The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are… Expand The neural crest is a multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many… Expand In neural crest formation, transcription factors, such as group E Sox and Snail1/Snail2 (Slug) regulate subsequent epithelial… Expand FGF, WNT, and BMP signaling promote neural crest formation at the neural plate boundary in vertebrate embryos. To understand how… Expand The SOX family of transcription factors has been implicated in cell fate specification during embryogenesis. One member of this… Expand The Wnt family of secreted signalling molecules are essential in embryo development and tumour formation. The Frizzled (Fz… Expand The neural crest is a transient population of multipotent precursor cells named for its site of origin at the crest of the… Expand We have investigated the molecular interactions underlying neural crest formation in Xenopus. Using chordin overexpression to… Expand