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Cancerous stem cells can arise from pediatric brain tumors
TLDR
It is found that tumor-derived progenitors form neurospheres that can be passaged at clonal density and are able to self-renew, which may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors. Expand
The amphioxus genome and the evolution of the chordate karyotype
TLDR
Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization. Expand
Neural crest induction in Xenopus: evidence for a two-signal model.
TLDR
It is found that chordin-induced neural plate tissue can be induced to adopt neural crest fates by members of the FGF and Wnt families, growth factors that have previously been shown to posteriorize induced neural tissue. Expand
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.
TLDR
The EMT events that build the embryo are reviewed and two prototypical processes governed by EMT in amniotes are discussed: gastrulation and neural crest formation. Expand
Gene-regulatory interactions in neural crest evolution and development.
TLDR
This review outlines the gene-regulatory interactions driving neural crest development and compares these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus, and suggests that later activation of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty. Expand
A gene regulatory network orchestrates neural crest formation
TLDR
The current understanding of these processes is reviewed and the molecular players that are involved in the neural crest gene regulatory network are discussed. Expand
Specification of the neural crest occurs during gastrulation and requires Pax7
TLDR
It is reported that neural crest induction is underway during gastrulation and well before proper neural plate appearance, and that Pax7 has a crucial function during neural crest development. Expand
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
TLDR
The results demonstrate that Eph-family receptor tyrosine kinases and their transmembrane ligands are involved in interactions between neural crest and sclerotomal cells, mediating an inhibitory activity necessary to constrain neural precursors to specific territories in the developing nervous system. Expand
Ectodermal Wnt Function as a Neural Crest Inducer
TLDR
It is shown that, in avians, Wnt6 is localized in ectoderm and in vivo inhibition of Wnt signaling perturbs neural crest formation, which suggests that Wnt molecules are necessary and sufficient to induce neural crest cells in avian embryos. Expand
Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite.
TLDR
Wnt-11 is used as a molecular marker for the medial compartment of dermomyotome (the 'medial lip') to demonstrate that BMP in the dorsal neural tube indirectly induces formation of the medial lip by up-regulating Wnt-1 and Wnt -3a expression in the neural tube. Expand
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