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nepicastat

Known as: 5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphth-2-yl)-1,3-dihydroimidazole-2-thione 
 
National Institutes of Health

Papers overview

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2015
2015
The interaction of etamicastat, a novel peripherally acting dopamine-β-hydroxylase (DBH) inhibitor, with the enzyme was studied… Expand
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2015
2015
Abstract 1. This study explores the impact of permeability and P-glycoprotein (P-gp) efflux, upon brain exposure to etamicastat… Expand
2014
2014
The dopamine‐beta‐hydroxylase inhibitor nepicastat has been shown to reproduce disulfiram ability to suppress the reinstatement… Expand
2014
2014
BACKGROUND Recent experimental data indicate that treatment with the selective dopamine β-hydroxylase inhibitor, nepicastat… Expand
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Highly Cited
2013
Highly Cited
2013
Although norepinephrine (NE) does not typically modulate cocaine self-administration under traditional schedules of reinforcement… Expand
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2013
2013
Craving for chocolate is a common phenomenon, which may evolve to an addictive-like behaviour and contribute to obesity… Expand
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2011
2011
Background Human dopamine β-hydroxylase (DBH) is an important therapeutic target for complex traits. Several single nucleotide… Expand
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Highly Cited
2000
Highly Cited
2000
Background—Inhibition of dopamine β-hydroxylase (DBH) results in a decrease in norepinephrine synthesis. The present study was a… Expand
2000
2000
BACKGROUND Inhibition of dopamine beta-hydroxylase (DBH) results in a decrease in norepinephrine synthesis. The present study was… Expand
Highly Cited
1997
Highly Cited
1997
1 Inhibitory modulation of sympathetic nerve function may have a favourable impact on the progression of congestive heart failure… Expand