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Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.
- M. Bonifácio, P. Palma, L. Almeida, P. Soares-da-Silva
- Biology, PsychologyCNS drug reviews
- 1 September 2007
The current knowledge on the enzyme catechol-O-methyltransferase (COMT) and the role of COMT inhibitors in PD are reviewed and conversion of levodopa to dopamine at the target region in the brain and facilitation of the continuous action of this amine at the receptor sites are reviewed.
Eslicarbazepine acetate (BIA 2-093)
Pharmacokinetics and drug interactions of eslicarbazepine acetate
Eslicarbazepine acetate (ESL) is a novel once‐daily antiepileptic drug (AED) approved in Europe since 2009 that was found to be efficacious and well tolerated in a phase III clinical program in adult…
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers.
- L. Almeida, M. Vaz‐da‐Silva, P. Soares-da-Silva
- Medicine, BiologyMolecular nutrition & food research
- 1 May 2009
In conclusion, repeated administration was well-tolerated but produced relatively low plasma concentrations of trans-resveratrol, despite the high doses and short dosing interval used.
Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy
Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial
Effect of opicapone on levodopa pharmacokinetics, catechol‐O‐methyltransferase activity and motor fluctuations in patients with Parkinson's disease
This study investigated the effects of OPC in comparison with placebo on levodopa pharmacokinetics, tolerability and safety, COMT activity and motor response tolevodopa in Parkinson's disease patients with motor fluctuations.
Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024
- A. Ambrósio, P. Soares-da-Silva, C. Carvalho, A. Carvalho
- Psychology, ChemistryNeurochemical Research
- 1 February 2002
The available data indicate that the anticonvulsant efficacy of these AEDs is mainly due to the inhibition of sodium channel activity, which is in line with previous reports on these drugs.
Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(−)-10,11-dihydro-10-hydroxy carbamazepine
Single‐Dose and Steady‐State Pharmacokinetics of Eslicarbazepine Acetate (BIA 2–093) in Healthy Elderly and Young Subjects
- L. Almeida, A. Falcão, J. Maia, D. Mazur, M. Gellert, P. Soares-da-Silva
- Chemistry, BiologyJournal of clinical pharmacology
- 1 September 2005
This drug is chemically related to carbamazepine andoxcarbazepine but has been specifically designed to avoid the production of toxic metabolites and to overcome enantiomeric impurity and the unnecessary production of enantiomers ordiastereoisomers of metabolites and conjugates.