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negative regulation of transferase activity

Known as: down-regulation of transferase activity, transferase inhibitor, downregulation of transferase activity 
Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

biological control
transferase activity

Papers overview

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Highly Cited
2011
Highly Cited
2011
The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.
Farnesyl transferase inhibitors (FTIs) inhibit the farnesylation of proteins, including RAS and RHEB (Ras homolog enriched in… Expand
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2010
2010
A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells
Prenylation inhibitors have gained increasing attention as potential therapeutics for cancer. Initial work focused on inhibitors… Expand
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Highly Cited
2005
Highly Cited
2005
The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling
Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras… Expand
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Highly Cited
2001
Highly Cited
2001
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.
P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many… Expand
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Highly Cited
2000
Highly Cited
2000
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction… Expand
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Highly Cited
2000
Highly Cited
2000
The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo
Purpose: SCH66336 is an orally active, farnesyl protein transferase inhibitor. SCH66336 inhibits ras farnesylation in tumor cells… Expand
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1999
1999
Combination therapy with the farnesyl protein transferase inhibitor SCH66336 and SCH58500 (p53 adenovirus) in preclinical cancer models.
SCH66336 is a p.o.-active, farnesyl protein transferase inhibitor. SCH66336 inhibits farnesylation of RAS and other proteins in… Expand
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1999
1999
The up-regulation of vascular endothelial growth factor in mutated Ha-ras HaCaT cell lines is reduced by a farnesyl transferase inhibitor.
The induction of tumor angiogenesis is mediated in particular by an increased production of VEGF. As ras oncogene is implicated… Expand
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Highly Cited
1998
Highly Cited
1998
A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells*
Farnesylation is required for the membrane partition and function of several proteins, including Ras. Farnesyl-protein… Expand
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1996
1996
Inhibition of cell growth of human hepatoma cell line (HepG2) by a farnesyl protein transferase inhibitor: A preferential suppression of ras farnesylation
So far, treatment with anti‐cancer agents has failed to achieve satisfactory results in hepatocellular carcinoma. In the process… Expand
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