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negative regulation of transferase activity
Known as:
down-regulation of transferase activity
, transferase inhibitor
, downregulation of transferase activity
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Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
biological control
transferase activity
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Novel histone methyl transferase inhibitor and use thereof
디 루시오에릭
,
모리시타마사요
,
이태호
2014
Corpus ID: 181859141
The present invention relates to a novel histone methyl transferase inhibitor. The present invention also relates to a…
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2006
2006
Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for…
N. Appels
,
H. Rosing
,
T. Stephens
,
J. Schellens
,
J. Beijnen
Analytical Chemistry
2006
Corpus ID: 27123376
Biological effectiveness is an important parameter in determining optimal dosages of molecular targeted drugs, such as farnesyl…
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2005
2005
Nitrogen-containing bisphosphonate incadronate augments the inhibitory effect of farnesyl transferase inhibitor tipifarnib on the growth of fresh and cloned myeloma cells in vitro
N. Ochiai
,
N. Yamada
,
+6 authors
C. Shimazaki
Leukemia and Lymphoma
2005
Corpus ID: 10247060
RAS gene mutations occur in 30 – 40% of multiple myeloma (MM) patients. Farnesylation is the first step in the post-translational…
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2005
2005
Effect of the Farnesyl Transferase Inhibitor L-744,832 on the Colon Cancer Cell Line DLD-1 and Its Combined Use with Radiation and 5-FU
H. Kavgacı
,
Feyyaz Özdemir
,
E. Ovalı
,
A. Yavuz
,
M. Yavuz
,
F. Aydın
Chemotherapy
2005
Corpus ID: 25860798
Background: Ras oncogenes are found in 25% of human tumors and they significantly affect prognosis. One of the major fields…
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2004
2004
Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability.
F. Njoroge
,
B. Vibulbhan
,
+5 authors
V. Girijavallabhan
Bioorganic & Medicinal Chemistry Letters
2004
Corpus ID: 479417
2002
2002
Chiral liquid chromatography separation and chiroptical properties of the enantiomers of dimethyl alpha-hydroxyfarnesylphosphonate, a precursor of a farnesyl protein transferase inhibitor.
S. Caccamese
,
Giovanna Scivoli
,
Yanming Du
,
D. Wiemer
Journal of Chromatography A
2002
Corpus ID: 9727734
Highly Cited
2001
Highly Cited
2001
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.
E. Wang
,
Christopher N. Casciano
,
Robert P. Clement
,
William W. Johnson
Cancer Research
2001
Corpus ID: 6786441
P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many…
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1996
1996
A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A.
N. Argade
,
R. Naik
Bioorganic & Medicinal Chemistry
1996
Corpus ID: 43501834
1991
1991
Mechanisms of the glucose lowering effect of a carnitine palmitoyl transferase inhibitor in normal and diabetic rats.
C. Martin
,
M. Odeon
,
R. Cohen
,
M. Beylot
Metabolism: Clinical and Experimental
1991
Corpus ID: 31714132
1979
1979
Effect of intestinal gamma-glutamyl transferase inhibitor on the amount of gamma-glutamyl metabolites in mouse.
K. Sobiech
,
A. Szewczuk
Folia histochemica et cytochemica
1979
Corpus ID: 23799611
Experimental mice fed a balanced rodent chow, called LSM fodder, had markedly lower gamma-glutamyl transferase activity in the…
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