negative regulation of transferase activity

Known as: down-regulation of transferase activity, transferase inhibitor, downregulation of transferase activity 
Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group… (More)
National Institutes of Health

Papers overview

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2011
2011
Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-14, and NF90-8 to nanomolar concentrations… (More)
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2010
2010
Prenylation inhibitors have gained increasing attention as potential therapeutics for cancer. Initial work focused on inhibitors… (More)
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Highly Cited
2005
Highly Cited
2005
Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras… (More)
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2002
2002
A commercially available, cell permeable, protein-farnesyl transferase inhibitor interfered with the serum-induced morphological… (More)
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2001
2001
P-glycoprotein (Pgp)-mediated drug efflux is a major factor contributing to the variance of absorption and distribution of many… (More)
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Highly Cited
2000
Highly Cited
2000
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction… (More)
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2000
2000
Purpose: SCH66336 is an orally active, farnesyl protein transferase inhibitor. SCH66336 inhibits ras farnesylation in tumor cells… (More)
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1999
1999
The induction of tumor angiogenesis is mediated in particular by an increased production of VEGF. As ras oncogene is implicated… (More)
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1999
1999
SCH66336 is a p.o.-active, farnesyl protein transferase inhibitor. SCH66336 inhibits farnesylation of RAS and other proteins in… (More)
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1995
1995
BZA-5B is a peptidomimetic inhibitor of protein farnesylation in mammalian cells. We have examined the specificity of this… (More)
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