necrostatin-1

Known as: Nec-1 compound 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Necroptosis has emerged as an important form of regulated necrotic cell death, which can occur during mouse development and is… (More)
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Highly Cited
2012
Highly Cited
2012
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK… (More)
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Highly Cited
2012
Highly Cited
2012
Loss of kidney function in renal ischemia/reperfusion injury is due to programmed cell death, but the contribution of necroptosis… (More)
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Highly Cited
2011
Highly Cited
2011
Necrostatin-1 inhibits receptor-interacting protein (RIP)-1 kinase and programmed necrosis and is neuroprotective in adult rodent… (More)
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Review
2010
Review
2010
The family of death receptors plays a critical role in regulating cell number and eliminating harmful or virally infected cells… (More)
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Highly Cited
2008
Highly Cited
2008
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor… (More)
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Highly Cited
2008
Highly Cited
2008
Necroptosis is a newly identified type of programmed necrosis initiated by the activation of tumor necrosis factor alpha… (More)
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Highly Cited
2007
Highly Cited
2007
Necrostatin-1 (Nec-1), a small tryptophan-based molecule, was recently reported to protect the cerebral cortex against ischemia… (More)
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Highly Cited
2007
Highly Cited
2007
Glutamate, a major excitatory neurotransmitter in the CNS, plays a critical role in neurological disorders such as stroke and… (More)
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Highly Cited
2005
Highly Cited
2005
The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms… (More)
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