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necrostatin-1

Known as: Nec-1 compound 
National Institutes of Health

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2 relations

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ImidazolesIndoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Rip 1-dependent endothelial necroptosis participates in ischemia-reperfusion injury of mouse flap.
2017
2017
A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model
2016
2016
Effects of necrostatin-1, an inhibitor of necroptosis, and its inactive analogue Nec-1i on basal cardiovascular function.
Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury… 
2014
2014
Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms.
PURPOSE To evaluate the mechanism of tamoxifen-induced cell death in human cultured RPE cells, and to investigate concurrent cell… 
2013
2013
Study of Cardioprotective Effects of Necroptosis Inhibitors on Isolated Rat Heart Subjected to Global Ischemia–Reperfusion
The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model… 
2012
2012
Protease Activity of Procaspase-8 Is Essential for Cell Survival by Inhibiting Both Apoptotic and Nonapoptotic Cell Death Dependent on Receptor-interacting Protein Kinase 1 (RIP1) and RIP3*
Background: Caspase-8 inhibits necrosis by regulating RIP1 and RIP3. Results: Caspase-8 knockdown T-cells simultaneously… 
2012
2012
Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine
Abstract We show that the plant quaternary benzo[c]phenanthridine alkaloid sanguilutine (SL) is a strong inducer of caspase… 
Highly Cited
2011
Highly Cited
2011
TNFα-induced necroptosis and autophagy via supression of the p38-NF-κB survival pathway in L929 cells.
Tumor necrosis factor alpha (TNFα) has been reported to induce necroptosis and autophagy, but its mechanisms remain unclear. In… 
2011
2011
Light- and sodium azide-induced death of RGC-5 cells in culture occurs via different mechanisms
Previous studies have shown that light impinging on the retina in situ has the capacity to kill neuronal and non-neuronal cells… 
2009
2009
Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites.
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